(E)-(4S,5S)-4-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-6-(tert-butyl-diphenyl-silanyloxy)-5-methyl-hex-2-enoic acid methyl ester

Base Information

Chemical Name:(E)-(4S,5S)-4-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-6-(tert-butyl-diphenyl-silanyloxy)-5-methyl-hex-2-enoic acid methyl ester
CAS No.:226067-16-9
Molecular Formula:C₃₄H₅₀N₂O₆Si
Molecular Weight:610.866
Hs Code.:

Synonyms:(E)-(4S,5S)-4-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-6-(tert-butyl-diphenyl-silanyloxy)-5-methyl-hex-2-enoic acid methyl ester

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Chemical Property of (E)-(4S,5S)-4-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-6-(tert-butyl-diphenyl-silanyloxy)-5-methyl-hex-2-enoic acid methyl ester

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Technology Process of (E)-(4S,5S)-4-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-6-(tert-butyl-diphenyl-silanyloxy)-5-methyl-hex-2-enoic acid methyl ester

There total 5 articles about (E)-(4S,5S)-4-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-6-(tert-butyl-diphenyl-silanyloxy)-5-methyl-hex-2-enoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50903-49-6
2(S)-((tert-butoxycarbonyl)amino)-3-methyl-butyric acid 2,3,4,5,6-pentafluorophenyl ester

: 474085-58-0
(E)-(4S,5S)-4-Amino-6-(tert-butyl-diphenyl-silanyloxy)-5-methyl-hex-2-enoic acid methyl ester

: 226067-16-9
(E)-(4S,5S)-4-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-6-(tert-butyl-diphenyl-silanyloxy)-5-methyl-hex-2-enoic acid methyl ester

Guidance literature:: With sodium hydrogencarbonate; In 1,4-dioxane; for 18h; Yield given;
DOI:10.1021/jo9904617

Reference yield:

: 194149-69-4
(E)-(4S, 5S)-methyl-4-azido-6-hydroxy-5-methyl-hex-2-enoate

: 226067-16-9
(E)-(4S,5S)-4-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-6-(tert-butyl-diphenyl-silanyloxy)-5-methyl-hex-2-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: imidazole / dimethylformamide / 6 h / 0 - 20 °C

2: SnCl₂; MeOH / 6 h / 0 - 20 °C

3: aq. NaHCO₃ / dioxane / 24 h / 20 °C

With 1H-imidazole; methanol; sodium hydrogencarbonate; tin(ll) chloride; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/ja0206700

Reference yield:

: 226067-14-7
(E)-(4S, 5S)-methyl-4-azido-6-(tert-butyldiphenylsiloxy)-5-methyl-hex-2-enoate

: 226067-16-9
(E)-(4S,5S)-4-((S)-2-tert-Butoxycarbonylamino-3-methyl-butyrylamino)-6-(tert-butyl-diphenyl-silanyloxy)-5-methyl-hex-2-enoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: SnCl₂; MeOH / 6 h / 0 - 20 °C

2: aq. NaHCO₃ / dioxane / 24 h / 20 °C

With methanol; sodium hydrogencarbonate; tin(ll) chloride; In 1,4-dioxane;
DOI:10.1021/ja0206700