(4R,5R)-2-(4-chloro-phenyl)-2-(2-nitro-ethyl)-[1,3]dioxolane-4,5-dicarboxylic acid dimethyl ester

Base Information

Chemical Name:(4R,5R)-2-(4-chloro-phenyl)-2-(2-nitro-ethyl)-[1,3]dioxolane-4,5-dicarboxylic acid dimethyl ester
CAS No.:688360-45-4
Molecular Formula:C₁₅H₁₆ClNO₈
Molecular Weight:373.747
Hs Code.:

Synonyms:(4R,5R)-2-(4-chloro-phenyl)-2-(2-nitro-ethyl)-[1,3]dioxolane-4,5-dicarboxylic acid dimethyl ester

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Chemical Property of (4R,5R)-2-(4-chloro-phenyl)-2-(2-nitro-ethyl)-[1,3]dioxolane-4,5-dicarboxylic acid dimethyl ester

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Technology Process of (4R,5R)-2-(4-chloro-phenyl)-2-(2-nitro-ethyl)-[1,3]dioxolane-4,5-dicarboxylic acid dimethyl ester

There total 3 articles about (4R,5R)-2-(4-chloro-phenyl)-2-(2-nitro-ethyl)-[1,3]dioxolane-4,5-dicarboxylic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 608-68-4
dimethyl L-tartrate

: 688360-42-1
1-chloro-4-(1,1-dimethoxy-3-nitro-propyl)-benzene

: 688360-45-4
(4R,5R)-2-(4-chloro-phenyl)-2-(2-nitro-ethyl)-[1,3]dioxolane-4,5-dicarboxylic acid dimethyl ester

Guidance literature:: With boron trifluoride diethyl etherate; In ethyl acetate; at 0 ℃; for 4h;
DOI:10.1016/j.tet.2004.01.039

Reference yield:

: 3946-29-0
3,4'-Dichloropropiophenone

: 688360-45-4
(4R,5R)-2-(4-chloro-phenyl)-2-(2-nitro-ethyl)-[1,3]dioxolane-4,5-dicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: p-TsOH / methanol / 5 h / Heating

2: 175 mg / BF₃*Et₂O / ethyl acetate / 4 h / 0 °C

With boron trifluoride diethyl etherate; toluene-4-sulfonic acid; In methanol; ethyl acetate;
DOI:10.1016/j.tet.2004.01.039

Reference yield:

: 62847-53-4
1-(4-chlorophenyl)-3-nitro-1-propanone

: 688360-45-4
(4R,5R)-2-(4-chloro-phenyl)-2-(2-nitro-ethyl)-[1,3]dioxolane-4,5-dicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: p-TsOH / methanol / 5 h / Heating

2: 175 mg / BF₃*Et₂O / ethyl acetate / 4 h / 0 °C

With boron trifluoride diethyl etherate; toluene-4-sulfonic acid; In methanol; ethyl acetate;
DOI:10.1016/j.tet.2004.01.039