Technology Process of 1-(3-(1,3-dioxolan-2-yl)propyl)-4-phenylcyclohexanol
There total 1 articles about 1-(3-(1,3-dioxolan-2-yl)propyl)-4-phenylcyclohexanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(3-(1,3-dioxolan-2-yl)propyl)magnesium bromide;
With
cerium(III) chloride;
In
tetrahydrofuran;
at 0 ℃;
for 1h;
Glovebox;
Inert atmosphere;
1-phenyl-4-cyclohexanone;
In
tetrahydrofuran;
at 0 ℃;
for 0.5h;
Glovebox;
Inert atmosphere;
DOI:10.1021/ja5026479
- Guidance literature:
-
With
(1,5-cyclooctadiene)(methoxy)iridium(I) dimer;
In
tetrahydrofuran;
at 20 ℃;
Glovebox;
Inert atmosphere;
DOI:10.1021/ja5026479
- Guidance literature:
-
Multi-step reaction with 3 steps
1: (1,5-cyclooctadiene)(methoxy)iridium(I) dimer / tetrahydrofuran / 20 °C / Glovebox; Inert atmosphere
2: norbornene; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 3,4,7,8-Tetramethyl-o-phenanthrolin / tetrahydrofuran / 16 h / 120 °C / Glovebox; Inert atmosphere
3: cesiumhydroxide monohydrate; tert.-butylhydroperoxide; tetrabutyl ammonium fluoride / N,N-dimethyl-formamide; decane / 80 °C / Sealed tube
With
tert.-butylhydroperoxide; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; cesiumhydroxide monohydrate; 3,4,7,8-Tetramethyl-o-phenanthrolin; norbornene; tetrabutyl ammonium fluoride;
In
tetrahydrofuran; decane; N,N-dimethyl-formamide;
3: |Tamao-Kumada Oxidation;
DOI:10.1021/ja5026479
