7-amino-6-(2-methyl-4-nitro-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Base Information

Chemical Name:7-amino-6-(2-methyl-4-nitro-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid
CAS No.:952202-52-7
Molecular Formula:C₁₄H₁₁N₅O₄
Molecular Weight:313.272
Hs Code.:

Synonyms:7-amino-6-(2-methyl-4-nitro-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

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Chemical Property of 7-amino-6-(2-methyl-4-nitro-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

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Technology Process of 7-amino-6-(2-methyl-4-nitro-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

There total 2 articles about 7-amino-6-(2-methyl-4-nitro-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 952202-53-8
C₁₆H₁₅N₅O₄

: 952202-52-7
7-amino-6-(2-methyl-4-nitro-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Guidance literature:: C₁₆H₁₅N₅O₄; With sodium hydroxide; ethanol; water; for 6.5h; Heating / reflux;

With acetic acid; In water; at 0 ℃;

Reference yield:

: 543683-45-0
2-(2-methyl-4-nitrophenyl)acetonitrile

: 952202-52-7
7-amino-6-(2-methyl-4-nitro-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene / 12 h / 20 - 120 °C

2.1: hydrogenchloride; acetic acid / ethanol / 5.5 h / Heating / reflux

3.1: sodium hydroxide; ethanol; water / 6.5 h / Heating / reflux

3.2: 0 °C

With hydrogenchloride; sodium hydroxide; ethanol; water; acetic acid; In ethanol; toluene;

Reference yield:

: 952202-52-7
7-amino-6-(2-methyl-4-nitro-phenyl)-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid

: [7-amino-6-(4-amino-2-methyl-phenyl)-pyrazolo[1,5-a]pyrimidin-3-yl]-(3-dimethylamino-pyrrolidin-1-yl)-methanone

Guidance literature:: Multi-step reaction with 2 steps

1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine / dmap / N,N-dimethyl-formamide / 17 h / 20 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 3 h / 750.08 Torr

With hydrogen; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; dmap; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide;