4-Bromo-benzenesulfonic acid (R)-1-((S)-2-bromo-9H-fluoren-9-yl)-ethyl ester

Base Information

• Chemical Name: 4-Bromo-benzenesulfonic acid (R)-1-((S)-2-bromo-9H-fluoren-9-yl)-ethyl ester
• CAS No.: 186450-31-7
• Molecular Formula: C₂₁H₁₆Br₂O₃S
• Molecular Weight: 508.23
• Mol file: 186450-31-7.mol

Synonyms:4-Bromo-benzenesulfonic acid (R)-1-((S)-2-bromo-9H-fluoren-9-yl)-ethyl ester

Chemical Property of 4-Bromo-benzenesulfonic acid (R)-1-((S)-2-bromo-9H-fluoren-9-yl)-ethyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 4-Bromo-benzenesulfonic acid (R)-1-((S)-2-bromo-9H-fluoren-9-yl)-ethyl ester

There total 2 articles about 4-Bromo-benzenesulfonic acid (R)-1-((S)-2-bromo-9H-fluoren-9-yl)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromo-9H-fluorene (1133-80-8) → 4-Bromo-benzenesulfonic acid (R)-1-((S)-2-bromo-9H-fluoren-9-yl)-ethyl ester (186450-31-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) BuLi / 1.) hexane, ether, < -50 deg C, 1.5 h, 2.) 10 min

2: CH₂Cl₂; pyridine / 3.5 h / Ambient temperature

With n-butyllithium; In pyridine; dichloromethane;

DOI:10.1021/ja962469t

Reference yield:

4-bromobenzenesulfonyl chloride (98-58-8) + (R,S)-2-bromo-9-(1-hydroxyethyl)fluorene (186450-19-1) → 4-Bromo-benzenesulfonic acid (R)-1-((S)-2-bromo-9H-fluoren-9-yl)-ethyl ester (186450-31-7)

Guidance literature:

In pyridine; dichloromethane; for 3.5h; Ambient temperature;

DOI:10.1021/ja962469t

upstream raw materials:

4-bromobenzenesulfonyl chloride

(R,S)-2-bromo-9-(1-hydroxyethyl)fluorene

2-bromo-9H-fluorene