3α-di(4-fluorophenyl)methoxymethyl-8-azabicyclo[3.2.1]octane

Base Information

Chemical Name:3α-di(4-fluorophenyl)methoxymethyl-8-azabicyclo[3.2.1]octane
CAS No.:915098-16-7
Molecular Formula:C₂₁H₂₃F₂NO
Molecular Weight:343.417
Hs Code.:

Synonyms:3α-di(4-fluorophenyl)methoxymethyl-8-azabicyclo[3.2.1]octane

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Chemical Property of 3α-di(4-fluorophenyl)methoxymethyl-8-azabicyclo[3.2.1]octane

Chemical Property:

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Technology Process of 3α-di(4-fluorophenyl)methoxymethyl-8-azabicyclo[3.2.1]octane

There total 4 articles about 3α-di(4-fluorophenyl)methoxymethyl-8-azabicyclo[3.2.1]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 915098-11-2
8-ethoxycarbonyl-3-hydroxymethyl-8-azabicyclo[3.2.1]oct-2-ene

: 915098-16-7
3α-di(4-fluorophenyl)methoxymethyl-8-azabicyclo[3.2.1]octane

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / 2 h / 160 °C

2: 70 percent / potassium hydroxide; hydrazine hydrate / ethane-1,2-diol / 3 h / Heating

3: 90 percent / hydrogen / Pd/C / methanol / 24 h / 20 °C / 2844.31 Torr

With potassium hydroxide; hydrogen; hydrazine hydrate; palladium on activated charcoal; In methanol; ethylene glycol;
DOI:10.1016/j.bmc.2006.07.051

Reference yield:

: 184368-77-2
8-ethoxycarbonyl-8-azabicyclo[3.2.1]oct-2-ene-3-carboxylic acid methyl ester

: 915098-16-7
3α-di(4-fluorophenyl)methoxymethyl-8-azabicyclo[3.2.1]octane

Guidance literature:: Multi-step reaction with 4 steps

1: 60 percent / lithium aluminum hydride / toluene / 0 °C

2: 80 percent / 2 h / 160 °C

3: 70 percent / potassium hydroxide; hydrazine hydrate / ethane-1,2-diol / 3 h / Heating

4: 90 percent / hydrogen / Pd/C / methanol / 24 h / 20 °C / 2844.31 Torr

With potassium hydroxide; lithium aluminium tetrahydride; hydrogen; hydrazine hydrate; palladium on activated charcoal; In methanol; ethylene glycol; toluene;
DOI:10.1016/j.bmc.2006.07.051

Reference yield:

: 915098-13-4
8-ethoxycarbonyl-3-di(4-fluorophenyl)methoxymethyl-8-azabicyclo[3.2.1]oct-2-ene

: 915098-16-7
3α-di(4-fluorophenyl)methoxymethyl-8-azabicyclo[3.2.1]octane

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / potassium hydroxide; hydrazine hydrate / ethane-1,2-diol / 3 h / Heating

2: 90 percent / hydrogen / Pd/C / methanol / 24 h / 20 °C / 2844.31 Torr

With potassium hydroxide; hydrogen; hydrazine hydrate; palladium on activated charcoal; In methanol; ethylene glycol;
DOI:10.1016/j.bmc.2006.07.051