6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-7-(1,2,3,6-tetrahydro-4-pyridinyl)-4-oxo-1,8-naphthyridine-3-carboxylic acid dihydrochhloride

Base Information

Chemical Name:6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-7-(1,2,3,6-tetrahydro-4-pyridinyl)-4-oxo-1,8-naphthyridine-3-carboxylic acid dihydrochhloride
CAS No.:134046-61-0
Molecular Formula:C₂₀H₁₄F₃N₃O₃*2ClH
Molecular Weight:474.267
Hs Code.:

Synonyms:6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-7-(1,2,3,6-tetrahydro-4-pyridinyl)-4-oxo-1,8-naphthyridine-3-carboxylic acid dihydrochhloride

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Chemical Property of 6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-7-(1,2,3,6-tetrahydro-4-pyridinyl)-4-oxo-1,8-naphthyridine-3-carboxylic acid dihydrochhloride

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Technology Process of 6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-7-(1,2,3,6-tetrahydro-4-pyridinyl)-4-oxo-1,8-naphthyridine-3-carboxylic acid dihydrochhloride

There total 4 articles about 6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-7-(1,2,3,6-tetrahydro-4-pyridinyl)-4-oxo-1,8-naphthyridine-3-carboxylic acid dihydrochhloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 134046-62-1
7-(1-Acetyl-1,2,3,6-tetrahydro-pyridin-4-yl)-1-(2,4-difluoro-phenyl)-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid

: 134046-61-0
6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-7-(1,2,3,6-tetrahydro-4-pyridinyl)-4-oxo-1,8-naphthyridine-3-carboxylic acid dihydrochhloride

Guidance literature:: With hydrogenchloride; at 50 - 60 ℃; for 24h;
DOI:10.1002/jhet.5570280133

Reference yield:

: 130579-43-0
1-Acetyl-1,2,3,6-tetrahydro-4-tributylstannyl-pyridine

: 134046-61-0
6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-7-(1,2,3,6-tetrahydro-4-pyridinyl)-4-oxo-1,8-naphthyridine-3-carboxylic acid dihydrochhloride

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / 2,6-di-t-butyl-4-methylphenol / PdCl₂(Ph₃P)2 / dimethylformamide / 7 h / Heating

2: 68 percent / 5N HCl / acetonitrile / 163 h / Ambient temperature

3: 91 percent / 5N HCl / 24 h / 50 - 60 °C

With hydrogenchloride; 2,6-di-tert-butyl-4-methyl-phenol; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/jhet.5570280133

Reference yield:

: 100491-29-0
ethyl 7-chloro-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate

: 134046-61-0
6-fluoro-1-(2,4-difluorophenyl)-1,4-dihydro-7-(1,2,3,6-tetrahydro-4-pyridinyl)-4-oxo-1,8-naphthyridine-3-carboxylic acid dihydrochhloride

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / 2,6-di-t-butyl-4-methylphenol / PdCl₂(Ph₃P)2 / dimethylformamide / 7 h / Heating

2: 68 percent / 5N HCl / acetonitrile / 163 h / Ambient temperature

3: 91 percent / 5N HCl / 24 h / 50 - 60 °C

With hydrogenchloride; 2,6-di-tert-butyl-4-methyl-phenol; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/jhet.5570280133