(S)-N-(2-fluorophenyl)-3-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)benzenesulfonamide

Base Information

Chemical Name:(S)-N-(2-fluorophenyl)-3-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)benzenesulfonamide
CAS No.:1235560-24-3
Molecular Formula:C₂₀H₂₂FN₃O₃S
Molecular Weight:403.477
Hs Code.:

Synonyms:(S)-N-(2-fluorophenyl)-3-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)benzenesulfonamide

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Chemical Property of (S)-N-(2-fluorophenyl)-3-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)benzenesulfonamide

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Technology Process of (S)-N-(2-fluorophenyl)-3-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)benzenesulfonamide

There total 3 articles about (S)-N-(2-fluorophenyl)-3-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 348-54-9
2-Fluoroaniline

: C₁₄H₁₇ClN₂O₃S

: 1235560-24-3
(S)-N-(2-fluorophenyl)-3-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)benzenesulfonamide

Guidance literature:: 2-Fluoroaniline; C₁₄H₁₇ClN₂O₃S; In dichloromethane; at 20 ℃;

With sodium carbonate; In methanol; dichloromethane; for 0.333333h;
DOI:10.1021/acsmedchemlett.5b00023

Reference yield:

: 93643-24-4
(S)-octahydropyrrolo[1,2-a]pyrazine

: 1235560-24-3
(S)-N-(2-fluorophenyl)-3-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 0.5 h / 20 °C

1.2: 5 h / 20 °C

2.1: dichloromethane / 20 °C

2.2: 0.33 h

In dichloromethane;
DOI:10.1021/acsmedchemlett.5b00023

Reference yield:

: 4052-92-0
3-chlorosulfonylbenzoyl dichloride

: 1235560-24-3
(S)-N-(2-fluorophenyl)-3-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 0.5 h / 20 °C

1.2: 5 h / 20 °C

2.1: dichloromethane / 20 °C

2.2: 0.33 h

In dichloromethane;
DOI:10.1021/acsmedchemlett.5b00023