S-{N₄-(benzyloxycarbonyl)-1-[(tert-butoxy)carbonylmethyl]cytosine-6-methyl}-N-Fmoc-L-cysteine methyl ester

Base Information

• Chemical Name: S-{N₄-(benzyloxycarbonyl)-1-[(tert-butoxy)carbonylmethyl]cytosine-6-methyl}-N-Fmoc-L-cysteine methyl ester
• CAS No.: 1275513-34-2
• Molecular Formula: C₃₈H₄₀N₄O₉S
• Molecular Weight: 728.823

Synonyms:S-{N₄-(benzyloxycarbonyl)-1-[(tert-butoxy)carbonylmethyl]cytosine-6-methyl}-N-Fmoc-L-cysteine methyl ester

Chemical Property of S-{N₄-(benzyloxycarbonyl)-1-[(tert-butoxy)carbonylmethyl]cytosine-6-methyl}-N-Fmoc-L-cysteine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of S-{N₄-(benzyloxycarbonyl)-1-[(tert-butoxy)carbonylmethyl]cytosine-6-methyl}-N-Fmoc-L-cysteine methyl ester

There total 3 articles about S-{N₄-(benzyloxycarbonyl)-1-[(tert-butoxy)carbonylmethyl]cytosine-6-methyl}-N-Fmoc-L-cysteine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

tert-butyl N4-(benzyloxycarbonyl)-6-(chloromethyl)cytosine-1-acetate (1275513-44-4) + 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-mercaptopropionic acid methyl ester (233266-69-8) → S-{N4-(benzyloxycarbonyl)-1-[(tert-butoxy)carbonylmethyl]cytosine-6-methyl}-N-Fmoc-L-cysteine methyl ester (1275513-34-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 32h; Inert atmosphere;

DOI:10.1021/ja200829s

Reference yield:

C20H25N3O8S → S-{N4-(benzyloxycarbonyl)-1-[(tert-butoxy)carbonylmethyl]cytosine-6-methyl}-N-Fmoc-L-cysteine methyl ester (1275513-34-2)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium chloride / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 32 h / 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/ja200829s

Reference yield:

tert-butyl N4-[(benzyloxy)carbonyl]-6-(hydroxymethyl)cytosine-1-acetate (1182206-87-6) → S-{N4-(benzyloxycarbonyl)-1-[(tert-butoxy)carbonylmethyl]cytosine-6-methyl}-N-Fmoc-L-cysteine methyl ester (1275513-34-2)

Guidance literature:

Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

2: lithium chloride / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 32 h / 20 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/ja200829s

upstream raw materials:

tert-butyl N₄-[(benzyloxy)carbonyl]-6-(hydroxymethyl)cytosine-1-acetate

tert-butyl N₄-(benzyloxycarbonyl)-6-(chloromethyl)cytosine-1-acetate

2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-mercaptopropionic acid methyl ester

Downstream raw materials:

S-[N₄-(benzyloxycarbonyl)-1-(carboxymethyl)cytosine-6-methyl]-N-Fmoc-L-cysteine methyl ester

S-{N₄-(benzyloxycarbonyl)-1-[(tert-butoxy)carbonylmethyl]cytosine-6-methyl}-L-cysteine methyl ester

{S-[N4-(benzyloxycarbonyl)-1-(ω-carbonylmethyl)cytosine-6-methyl]-N-Fmoc-L-cysteine methyl ester}-S-{N4-(benzyloxycarbonyl)-1-[(tert-butoxy)carbonylmethyl]cytosine-6-methyl}-L-cysteine methyl ester

{S-[N4-(benzyloxycarbonyl)-1-(ω-carbonylmethyl)cytosine-6-methyl]-N-Fmoc-L-cysteine methyl ester}-S-{N4-(benzyloxycarbonyl)-1-(carboxymethyl)cytosine-6-methyl}-L-cysteine methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1275513-34-2 S-{N₄-(benzyloxycarbonyl)-1-[(tert-butoxy)carbonylmethyl]cytosine-6-methyl}-N-Fmoc-L-cysteine methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send