6-chloro-2-hydroxy-N,N-dimethyl-3-{2-[(R)-1-((2R,5R)-5-methyltetrahydrofuran-2-yl)propylamino]-3,4-dioxocyclobut-1-enylamino}benzenesulfonamide

Base Information

Chemical Name:6-chloro-2-hydroxy-N,N-dimethyl-3-{2-[(R)-1-((2R,5R)-5-methyltetrahydrofuran-2-yl)propylamino]-3,4-dioxocyclobut-1-enylamino}benzenesulfonamide
CAS No.:1092388-85-6
Molecular Formula:C₂₀H₂₆ClN₃O₆S
Molecular Weight:471.962
Hs Code.:

Synonyms:6-chloro-2-hydroxy-N,N-dimethyl-3-{2-[(R)-1-((2R,5R)-5-methyltetrahydrofuran-2-yl)propylamino]-3,4-dioxocyclobut-1-enylamino}benzenesulfonamide

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Chemical Property of 6-chloro-2-hydroxy-N,N-dimethyl-3-{2-[(R)-1-((2R,5R)-5-methyltetrahydrofuran-2-yl)propylamino]-3,4-dioxocyclobut-1-enylamino}benzenesulfonamide

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Technology Process of 6-chloro-2-hydroxy-N,N-dimethyl-3-{2-[(R)-1-((2R,5R)-5-methyltetrahydrofuran-2-yl)propylamino]-3,4-dioxocyclobut-1-enylamino}benzenesulfonamide

There total 12 articles about 6-chloro-2-hydroxy-N,N-dimethyl-3-{2-[(R)-1-((2R,5R)-5-methyltetrahydrofuran-2-yl)propylamino]-3,4-dioxocyclobut-1-enylamino}benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1092389-22-4
6-chloro-3-((2-ethoxy-3,4-dioxocyclobut-1-en-1-yl)amino)-2-hydroxy-N,N-dimethylbenzenesulfonamide

: 1092389-32-6
(R)-1-((2R,5R)-5-methyltetrahydrofuran-2-yl)propylamine para-toluenesulfonate salt

: 1092388-85-6
6-chloro-2-hydroxy-N,N-dimethyl-3-{2-[(R)-1-((2R,5R)-5-methyltetrahydrofuran-2-yl)propylamino]-3,4-dioxocyclobut-1-enylamino}benzenesulfonamide

Guidance literature:: With triethylamine; In acetonitrile; for 0.75h; Heating / reflux;

Reference yield:

: 620-02-0
5-Methylfurfural

: 1092388-85-6
6-chloro-2-hydroxy-N,N-dimethyl-3-{2-[(R)-1-((2R,5R)-5-methyltetrahydrofuran-2-yl)propylamino]-3,4-dioxocyclobut-1-enylamino}benzenesulfonamide

Guidance literature:: Multi-step reaction with 9 steps

1.1: tetrahydrofuran / 5.5 h / Heating / reflux

2.1: ammonium sulfate / tetrahydrofuran / Heating / reflux

3.1: diethyl ether / 0.5 h / 22 - 35 °C

4.1: sulfuric acid / tert-butyl methyl ether; water / 0.5 h / 5 - 10 °C

4.2: pH 11

5.1: sodium peroxide; methylamine / ethanol; water / 3 h / 5 - 20 °C

5.2: 1 h / 0 - 20 °C

6.1: triethylamine / acetonitrile / 0.5 h / 0 - 20 °C

7.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

8.1: trifluoroacetic acid / dichloromethane / 3 h / 0 °C

9.1: triethylamine / acetonitrile / 0.75 h / Heating / reflux

With sodium peroxide; ammonium sulfate; sulfuric acid; hydrogen; triethylamine; methylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; tert-butyl methyl ether; water; acetonitrile;

Reference yield:

: 779340-42-0
(R)-2-{[1-(5-methylfuran-2-yl)-(E)-methylidene]amino}-2-phenylethanol

: 1092388-85-6
6-chloro-2-hydroxy-N,N-dimethyl-3-{2-[(R)-1-((2R,5R)-5-methyltetrahydrofuran-2-yl)propylamino]-3,4-dioxocyclobut-1-enylamino}benzenesulfonamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: ammonium sulfate / tetrahydrofuran / Heating / reflux

2.1: diethyl ether / 0.5 h / 22 - 35 °C

3.1: sulfuric acid / tert-butyl methyl ether; water / 0.5 h / 5 - 10 °C

3.2: pH 11

4.1: sodium peroxide; methylamine / ethanol; water / 3 h / 5 - 20 °C

4.2: 1 h / 0 - 20 °C

5.1: triethylamine / acetonitrile / 0.5 h / 0 - 20 °C

6.1: hydrogen / palladium 10% on activated carbon / methanol / 20 °C

7.1: trifluoroacetic acid / dichloromethane / 3 h / 0 °C

8.1: triethylamine / acetonitrile / 0.75 h / Heating / reflux

With sodium peroxide; ammonium sulfate; sulfuric acid; hydrogen; triethylamine; methylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; tert-butyl methyl ether; water; acetonitrile;