3,3-bis(trifluoromethyl)-1-chloro-1,1-bis(p-(trifluoromethyl)phenyl)-3H-2,1-benzoxabismole

Base Information

• Chemical Name: 3,3-bis(trifluoromethyl)-1-chloro-1,1-bis(p-(trifluoromethyl)phenyl)-3H-2,1-benzoxabismole
• CAS No.: 148419-44-7
• Molecular Formula: C₂₃H₁₂BiClF₁₂O
• Molecular Weight: 776.762
• Mol file: 148419-44-7.mol

Synonyms:3,3-bis(trifluoromethyl)-1-chloro-1,1-bis(p-(trifluoromethyl)phenyl)-3H-2,1-benzoxabismole

Chemical Property of 3,3-bis(trifluoromethyl)-1-chloro-1,1-bis(p-(trifluoromethyl)phenyl)-3H-2,1-benzoxabismole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,3-bis(trifluoromethyl)-1-chloro-1,1-bis(p-(trifluoromethyl)phenyl)-3H-2,1-benzoxabismole

There total 1 articles about 3,3-bis(trifluoromethyl)-1-chloro-1,1-bis(p-(trifluoromethyl)phenyl)-3H-2,1-benzoxabismole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

sulfuryl dichloride (7791-25-5) + 3,3-bis(trifluoromethyl)-1,1,1-tris(p-(trifluoromethyl)-phenyl)-3H-2,1-benzoxabismole (121882-73-3) → 3,3-bis(trifluoromethyl)-1-chloro-1,1-bis(p-(trifluoromethyl)phenyl)-3H-2,1-benzoxabismole (148419-44-7)

Guidance literature:

In dichloromethane; Ar; addn. of SO2Cl2 to a solution of the starting oxabismole at -78 ° C; the solution was warmed to room temperature and stirred for 14 h;; evaporation in vacuo; recrystn. of the residue; elem. anal.;;

DOI:10.1021/om00029a047

Reference yield: 94.8%

1,1,1,3,3,3-hexafluoro-2-(2-iodophenyl)-2-methoxypropane (150771-61-2) + 3,3-bis(trifluoromethyl)-1-chloro-1,1-bis(p-(trifluoromethyl)phenyl)-3H-2,1-benzoxabismole (148419-44-7) → 1,1-bis(p-(trifluoromethyl)phenyl)-1-(2-(2,2,2-trifluoro-1-methoxy-1-(trifluoromethyl)ethyl)phenyl)-3,3-bis(trifluoromethyl)-3H-2,1λ5-benzoxabismole

Guidance literature:

In diethyl ether; hexane; dropwise addn. of o-C6H4IC(CF3)2OMe (in ether) to BuLi (in hexane), stirring (-78°C, 1 h), addn. to cold soln. of Bi-compd. (in ether), warming to -30°C (during 5 h); quenching with aq. NH4Cl, chromy. (hexane/ethylacetate=10:1); elem. anal.;

DOI:10.1021/om00032a060

Reference yield: 74.2%

N,N'-dimethylbenzylamine (103-83-3) + 3,3-bis(trifluoromethyl)-1-chloro-1,1-bis(p-(trifluoromethyl)phenyl)-3H-2,1-benzoxabismole (148419-44-7) → 1,1-bis(p-(trifluoromethyl)phenyl)-1-(2-((N,N-dimethylamino)methyl)phenyl)-3,3-bis(trifluoromethyl)-3H-2,1λ5-benzoxabismole

Guidance literature:

With BuLi; In tetrahydrofuran; diethyl ether; hexane; dropwise addn. of dimethylbenzylamine (in ether) to BuLi (in hexane), stirring (-10°C, then room temp., 10 h), addn. to cold soln. of Bi-compd. (in THF), stirring (-10°C, 10 min), warming to room temp. (during 9 h); quenching with aq. NaHCO3, chromy. (hexane/ethylacetate=10:1); elem. anal.;

DOI:10.1021/om00032a060

upstream raw materials:

sulfuryl dichloride

3,3-bis(trifluoromethyl)-1,1,1-tris(p-(trifluoromethyl)-phenyl)-3H-2,1-benzoxabismole

Downstream raw materials:

3,3-bis(trifluoromethyl)-1,1bis(p-(trifluoromethyl)phenyl)-1-(p-methylphenyl)-3H-2,1-benzoxabismole