Technology Process of 2-[4-(2-benzyl-benzo[b]thiophen-3-yl)-4''-chloro-[1,1';3',1'']terphenyl-4'-yloxy]-3-phenyl-propionic acid methyl ester
There total 10 articles about 2-[4-(2-benzyl-benzo[b]thiophen-3-yl)-4''-chloro-[1,1';3',1'']terphenyl-4'-yloxy]-3-phenyl-propionic acid methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
triphenylphosphine; diethylazodicarboxylate;
In
benzene;
at 20 ℃;
for 0.5h;
DOI:10.1021/jm990560c
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 85 percent / Pd(OAc)2; aq. K2CO3 / acetone / 2 h / 65 °C
2.1: BBr3 / CH2Cl2 / 10 h / 20 °C
3.1: n-BuLi / tetrahydrofuran / 3 h / -40 °C
3.2: tetrahydrofuran / 0.5 h / 0 °C
4.1: hydrazine monohydrate; diethylene glycol / 1 h / 180 °C
4.2: KOH / 10 h / 130 °C
5.1: Br2; KOAc / acetic acid / 0.17 h / 5 °C
6.1: (dppf)PdCl2; K2CO3 / 1,2-dimethoxy-ethane
7.1: diethylazodicarboxylate; PPh3 / benzene / 0.5 h / 20 °C
With
palladium diacetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; n-butyllithium; bromine; potassium acetate; boron tribromide; potassium carbonate; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; diethylene glycol;
In
tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; acetic acid; acetone; benzene;
1.1: Cyclization / 2.1: demethylation / 3.1: Metallation / 3.2: Acylation / 4.1: Wolff-Kishner reduction / 4.2: Wolff-Kishner reduction / 5.1: Bromination / 6.1: Substitution / 7.1: Alkylation;
DOI:10.1021/jm990560c
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: n-BuLi; tetramethylenediamine / diethyl ether / 12 h / 20 °C
1.2: 23 percent / diethyl ether / 20 h / 20 °C
2.1: BBr3 / CH2Cl2 / 10 h / 20 °C
3.1: n-BuLi / tetrahydrofuran / 3 h / -40 °C
3.2: tetrahydrofuran / 0.5 h / 0 °C
4.1: hydrazine monohydrate; diethylene glycol / 1 h / 180 °C
4.2: KOH / 10 h / 130 °C
5.1: Br2; KOAc / acetic acid / 0.17 h / 5 °C
6.1: (dppf)PdCl2; K2CO3 / 1,2-dimethoxy-ethane
7.1: diethylazodicarboxylate; PPh3 / benzene / 0.5 h / 20 °C
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; bromine; potassium acetate; boron tribromide; potassium carbonate; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; diethylene glycol;
In
tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; dichloromethane; acetic acid; benzene;
1.1: Metallation / 1.2: Cyclization / 2.1: demethylation / 3.1: Metallation / 3.2: Acylation / 4.1: Wolff-Kishner reduction / 4.2: Wolff-Kishner reduction / 5.1: Bromination / 6.1: Substitution / 7.1: Alkylation;
DOI:10.1021/jm990560c