2-(1-{[2-(1-tert-butoxycarbonylamino-2-methyl-propyl)-1,5-dimethyl-1H-imidazole-4-carbonyl]-amino}-2-methyl-propyl)-1,5-dimethyl-1H-imidazole-4-carboxylic acid

Base Information

• Chemical Name: 2-(1-{[2-(1-tert-butoxycarbonylamino-2-methyl-propyl)-1,5-dimethyl-1H-imidazole-4-carbonyl]-amino}-2-methyl-propyl)-1,5-dimethyl-1H-imidazole-4-carboxylic acid
• CAS No.: 479666-72-3
• Molecular Formula: C₂₅H₄₀N₆O₅
• Molecular Weight: 504.63

Synonyms:2-(1-{[2-(1-tert-butoxycarbonylamino-2-methyl-propyl)-1,5-dimethyl-1H-imidazole-4-carbonyl]-amino}-2-methyl-propyl)-1,5-dimethyl-1H-imidazole-4-carboxylic acid

Chemical Property of 2-(1-{[2-(1-tert-butoxycarbonylamino-2-methyl-propyl)-1,5-dimethyl-1H-imidazole-4-carbonyl]-amino}-2-methyl-propyl)-1,5-dimethyl-1H-imidazole-4-carboxylic acid

Chemical Property:

Purity/Quality:

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Technology Process of 2-(1-{[2-(1-tert-butoxycarbonylamino-2-methyl-propyl)-1,5-dimethyl-1H-imidazole-4-carbonyl]-amino}-2-methyl-propyl)-1,5-dimethyl-1H-imidazole-4-carboxylic acid

There total 6 articles about 2-(1-{[2-(1-tert-butoxycarbonylamino-2-methyl-propyl)-1,5-dimethyl-1H-imidazole-4-carbonyl]-amino}-2-methyl-propyl)-1,5-dimethyl-1H-imidazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-((S)-1-{[2-((S)-1-tert-butoxycarbonylamino-2-methyl-propyl)-1,5-dimethyl-1H-imidazole-4-carbonyl]-amino}-2-methyl-propyl)-1,5-dimethyl-1H-imidazole-4-carboxylic acid methyl ester (479666-71-2) → 2-(1-{[2-(1-tert-butoxycarbonylamino-2-methyl-propyl)-1,5-dimethyl-1H-imidazole-4-carbonyl]-amino}-2-methyl-propyl)-1,5-dimethyl-1H-imidazole-4-carboxylic acid (479666-72-3)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; methanol; water; at 20 ℃;

DOI:10.1016/S0040-4039(02)01365-5

Reference yield:

2-((S)-1-tert-butoxycarbonylamino-2-methyl-propyl)-1,5-dimethyl-1H-imidazole-4-carboxylic acid (479666-61-0) → 2-(1-{[2-(1-tert-butoxycarbonylamino-2-methyl-propyl)-1,5-dimethyl-1H-imidazole-4-carbonyl]-amino}-2-methyl-propyl)-1,5-dimethyl-1H-imidazole-4-carboxylic acid (479666-72-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / (PhO)2P(O)N₃; N,N-diisopropylethylamine / dimethylformamide

2: LiOH / tetrahydrofuran; H₂O; methanol / 0 °C

With lithium hydroxide; diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

DOI:10.1039/b701999h

Reference yield:

2-((S)-1-amino-2-methyl-propyl)-1,5-dimethyl-1H-imidazole-4-carboxylic acid methyl ester hydrochloride salt → 2-(1-{[2-(1-tert-butoxycarbonylamino-2-methyl-propyl)-1,5-dimethyl-1H-imidazole-4-carbonyl]-amino}-2-methyl-propyl)-1,5-dimethyl-1H-imidazole-4-carboxylic acid (479666-72-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / (PhO)2P(O)N₃; N,N-diisopropylethylamine / dimethylformamide

2: LiOH / tetrahydrofuran; H₂O; methanol / 0 °C

With lithium hydroxide; diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

DOI:10.1039/b701999h

upstream raw materials:

2-((S)-1-{[2-((S)-1-tert-butoxycarbonylamino-2-methyl-propyl)-1,5-dimethyl-1H-imidazole-4-carbonyl]-amino}-2-methyl-propyl)-1,5-dimethyl-1H-imidazole-4-carboxylic acid methyl ester

2-((S)-1-tert-butoxycarbonylamino-2-methyl-propyl)-1,5-dimethyl-1H-imidazole-4-carboxylic acid

t-Boc-L-valine

N²-(tert-butoxycarbonyl)-N¹-(1-methoxycarbonyl-2-oxopropyl)valinamide

Downstream raw materials:

2-(1-{[2-(1-amino-2-methyl-propyl)-1,5-dimethyl-1H-imidazole-4-carbonyl]-amino}-2-methyl-propyl)-1,5-dimethyl-1H-imidazole-4-carboxylic acid

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