4-[(tert-butoxycarbonyl)amino]-2-hydroxybenzoic acid

Base Information

• Chemical Name: 4-[(tert-butoxycarbonyl)amino]-2-hydroxybenzoic acid
• CAS No.: 184033-42-9
• Molecular Formula: C₁₂H₁₅NO₅
• Molecular Weight: 253.255
• Mol file: 184033-42-9.mol

Synonyms:4-[(tert-butoxycarbonyl)amino]-2-hydroxybenzoic acid

Chemical Property of 4-[(tert-butoxycarbonyl)amino]-2-hydroxybenzoic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

4-tert-Butoxycarbonylamino-2-hydroxy-benzoicacid 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[(tert-butoxycarbonyl)amino]-2-hydroxybenzoic acid

There total 7 articles about 4-[(tert-butoxycarbonyl)amino]-2-hydroxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

methyl 4-[(tert-butoxycarbonyl)amino]-2-hydroxybenzoate → 4-[(tert-butoxycarbonyl)amino]-2-hydroxybenzoic acid (184033-42-9)

Guidance literature:

With water; sodium hydroxide; In 1,4-dioxane; at 40 ℃;

Reference yield: 93.0%

di-tert-butyl dicarbonate (24424-99-5) + 4-Aminosalicylic acid (65-49-6) → 4-[(tert-butoxycarbonyl)amino]-2-hydroxybenzoic acid (184033-42-9)

Guidance literature:

With sodium hydroxide; In ethanol; water; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.cgd.8b01921

Reference yield: 92.0%

tert-butyldicarbonate (34619-03-9) + 4-Aminosalicylic acid (65-49-6) → 4-[(tert-butoxycarbonyl)amino]-2-hydroxybenzoic acid (184033-42-9)

Guidance literature:

4-Aminosalicylic acid; With sodium hydroxide; In ethanol; water; at 5 - 10 ℃;

tert-butyldicarbonate; In ethanol; water; at 5 - 10 ℃;

In ethanol; water;

upstream raw materials:

di-tert-butyl dicarbonate

4-Aminosalicylic acid

tert-butyldicarbonate

methyl 4-aminosalicylate

Downstream raw materials:

ethyl 4-(t-butoxycarbonylamino)-2-hydroxybenzoate

C₁₄H₁₇NO₆