(E)-1-[4-(2-benzofurancarbonyl)piperazinyl]-3-phenyl-2-propenone

Base Information

• Chemical Name: (E)-1-[4-(2-benzofurancarbonyl)piperazinyl]-3-phenyl-2-propenone
• CAS No.: 1337989-51-1
• Molecular Formula: C₂₂H₂₀N₂O₃
• Molecular Weight: 360.412
• Mol file: 1337989-51-1.mol

Synonyms:(E)-1-[4-(2-benzofurancarbonyl)piperazinyl]-3-phenyl-2-propenone

Chemical Property of (E)-1-[4-(2-benzofurancarbonyl)piperazinyl]-3-phenyl-2-propenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-1-[4-(2-benzofurancarbonyl)piperazinyl]-3-phenyl-2-propenone

There total 1 articles about (E)-1-[4-(2-benzofurancarbonyl)piperazinyl]-3-phenyl-2-propenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

(E)-3-phenylacrylic acid (140-10-3) + benzofuran-2-yl(piperazin-1-yl)methanone (41717-31-1) → (E)-1-[4-(2-benzofurancarbonyl)piperazinyl]-3-phenyl-2-propenone (1337989-51-1)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 20h; Inert atmosphere;

DOI:10.1016/j.bmcl.2011.08.029

Reference yield: 68.0%

(E)-1-[4-(2-benzofurancarbonyl)piperazinyl]-3-phenyl-2-propenone (1337989-51-1) → (E)-1-(2-benzofuranylmethyl)-4-cinnamamylpiperazine (1316890-69-3)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃; Reflux; Inert atmosphere;

DOI:10.1016/j.bmcl.2011.08.029

Reference yield:

(E)-1-[4-(2-benzofurancarbonyl)piperazinyl]-3-phenyl-2-propenone (1337989-51-1) → 1-(2-benzofuranylmethyl)-4-(3-phenylpropyl)piperazine (1337989-63-5)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / diethyl ether / 0 °C / Reflux; Inert atmosphere

2: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol; water / 16 h / 20 °C / Inert atmosphere

With hydrogenchloride; lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; In methanol; diethyl ether; water;

DOI:10.1016/j.bmcl.2011.08.029

upstream raw materials:

(E)-3-phenylacrylic acid

benzofuran-2-yl(piperazin-1-yl)methanone

Downstream raw materials:

(E)-1-(2-benzofuranylmethyl)-4-cinnamamylpiperazine

1-(2-benzofuranylmethyl)-4-(3-phenylpropyl)piperazine