ethyl 4-(5-(3-phenoxybenzamido)-2,3'-bipyridin-6'-yloxy)cyclohexanecarboxylate

Base Information

Chemical Name:ethyl 4-(5-(3-phenoxybenzamido)-2,3'-bipyridin-6'-yloxy)cyclohexanecarboxylate
CAS No.:1360801-97-3
Molecular Formula:C₃₂H₃₁N₃O₅
Molecular Weight:537.615
Hs Code.:

Synonyms:ethyl 4-(5-(3-phenoxybenzamido)-2,3'-bipyridin-6'-yloxy)cyclohexanecarboxylate

Suppliers and Price of ethyl 4-(5-(3-phenoxybenzamido)-2,3'-bipyridin-6'-yloxy)cyclohexanecarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of ethyl 4-(5-(3-phenoxybenzamido)-2,3'-bipyridin-6'-yloxy)cyclohexanecarboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of ethyl 4-(5-(3-phenoxybenzamido)-2,3'-bipyridin-6'-yloxy)cyclohexanecarboxylate

There total 5 articles about ethyl 4-(5-(3-phenoxybenzamido)-2,3'-bipyridin-6'-yloxy)cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3739-38-6
3-phenoxybenzoic acid

: 1275993-34-4
ethyl 4-(5-amino-2,3'-bipyridin-6'-yloxy)cyclohexanecarboxylate

: 1360801-97-3
ethyl 4-(5-(3-phenoxybenzamido)-2,3'-bipyridin-6'-yloxy)cyclohexanecarboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃; for 17h;

Reference yield:

: 3618-04-0,75877-66-6,17159-80-7
4-hydroxycyclohexyl carboxylic acid ethyl ester

: 1360801-97-3
ethyl 4-(5-(3-phenoxybenzamido)-2,3'-bipyridin-6'-yloxy)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 17 h / 20 °C

2: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 15 h / Reflux

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 15 h / Reflux

4: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 17 h / 20 °C

With di-isopropyl azodicarboxylate; potassium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;

Reference yield:

: 13466-38-1
5-bromopyridin-2-ol

: 1360801-97-3
ethyl 4-(5-(3-phenoxybenzamido)-2,3'-bipyridin-6'-yloxy)cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 17 h / 20 °C

2: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 15 h / Reflux

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 15 h / Reflux

4: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 17 h / 20 °C

With di-isopropyl azodicarboxylate; potassium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;