3-(4-methoxy-3-methyl-phenyl)-4,4-dimethyl-3-vinyl-hept-6-enoic acid ethyl ester

Base Information

Chemical Name:3-(4-methoxy-3-methyl-phenyl)-4,4-dimethyl-3-vinyl-hept-6-enoic acid ethyl ester
CAS No.:603985-22-4
Molecular Formula:C₂₁H₃₀O₃
Molecular Weight:330.467
Hs Code.:

Synonyms:3-(4-methoxy-3-methyl-phenyl)-4,4-dimethyl-3-vinyl-hept-6-enoic acid ethyl ester

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Chemical Property of 3-(4-methoxy-3-methyl-phenyl)-4,4-dimethyl-3-vinyl-hept-6-enoic acid ethyl ester

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Technology Process of 3-(4-methoxy-3-methyl-phenyl)-4,4-dimethyl-3-vinyl-hept-6-enoic acid ethyl ester

There total 6 articles about 3-(4-methoxy-3-methyl-phenyl)-4,4-dimethyl-3-vinyl-hept-6-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 78-39-7
Triethyl orthoacetate

: (Z)-3-(4-Methoxy-3-methyl-phenyl)-4,4-dimethyl-hepta-2,6-dien-1-ol

: 603985-22-4
3-(4-methoxy-3-methyl-phenyl)-4,4-dimethyl-3-vinyl-hept-6-enoic acid ethyl ester

Guidance literature:: With propionic acid; at 180 ℃; for 48h;
DOI:10.1016/S0040-4039(02)02734-X

Reference yield:

: 14804-31-0
2-methyl-4-bromoanisole

: 603985-22-4
3-(4-methoxy-3-methyl-phenyl)-4,4-dimethyl-3-vinyl-hept-6-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 79 percent / Li / tetrahydrofuran / 0.75 h

2: 89 percent / PCC; silica gel / CH₂Cl₂ / 2 h

3: 80 percent / tetrahydrofuran / 4 h

4: 76 percent / PCC; silica gel / CH₂Cl₂ / 24 h

5: 81 percent / NaBH₄ / methanol / 0 - 5 °C

6: 45 percent / EtCOOH / 48 h / 180 °C

With sodium tetrahydroborate; silica gel; lithium; propionic acid; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane; 1: Barbier reaction / 6: Claisen rearrangement;
DOI:10.1016/S0040-4039(02)02734-X

Reference yield:

: 603985-18-8
1-(4-methoxy-3-methyl-phenyl)-2,2-dimethyl-pent-4-en-1-one

: 603985-22-4
3-(4-methoxy-3-methyl-phenyl)-4,4-dimethyl-3-vinyl-hept-6-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / tetrahydrofuran / 4 h

2: 76 percent / PCC; silica gel / CH₂Cl₂ / 24 h

3: 81 percent / NaBH₄ / methanol / 0 - 5 °C

4: 45 percent / EtCOOH / 48 h / 180 °C

With sodium tetrahydroborate; silica gel; propionic acid; pyridinium chlorochromate; In tetrahydrofuran; methanol; dichloromethane; 4: Claisen rearrangement;
DOI:10.1016/S0040-4039(02)02734-X