N₂-{2-[1,3-dihydro-2H-isoindol-2-yl(methyl)amino]-2-oxoethyl}-N₂-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-N₁-[2-(4-hydroxypiperidin-1-yl)ethyl]glycinamide

Base Information

• Chemical Name: N₂-{2-[1,3-dihydro-2H-isoindol-2-yl(methyl)amino]-2-oxoethyl}-N₂-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-N₁-[2-(4-hydroxypiperidin-1-yl)ethyl]glycinamide
• CAS No.: 1190893-62-9
• Molecular Formula: C₃₀H₃₉N₇O₄
• Molecular Weight: 561.684

Synonyms:N₂-{2-[1,3-dihydro-2H-isoindol-2-yl(methyl)amino]-2-oxoethyl}-N₂-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-N₁-[2-(4-hydroxypiperidin-1-yl)ethyl]glycinamide

Chemical Property of N₂-{2-[1,3-dihydro-2H-isoindol-2-yl(methyl)amino]-2-oxoethyl}-N₂-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-N₁-[2-(4-hydroxypiperidin-1-yl)ethyl]glycinamide

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Technology Process of N₂-{2-[1,3-dihydro-2H-isoindol-2-yl(methyl)amino]-2-oxoethyl}-N₂-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-N₁-[2-(4-hydroxypiperidin-1-yl)ethyl]glycinamide

There total 2 articles about N₂-{2-[1,3-dihydro-2H-isoindol-2-yl(methyl)amino]-2-oxoethyl}-N₂-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-N₁-[2-(4-hydroxypiperidin-1-yl)ethyl]glycinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

4-HYDROXYPIPERIDINE (5382-16-1) + N2-{2-[1,3-dihydro-2H-isoindol-2-yl(methyl)amino]-2-oxoethyl}-N2-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-N1-(2-bromoethyl)glycinamide (1190893-61-8) → N2-{2-[1,3-dihydro-2H-isoindol-2-yl(methyl)amino]-2-oxoethyl}-N2-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-N1-[2-(4-hydroxypiperidin-1-yl)ethyl]glycinamide (1190893-62-9)

Guidance literature:

In N,N-dimethyl-formamide; at 60 ℃; for 1.66667h;

Reference yield: 87.0%

4-HYDROXYPIPERIDINE (5382-16-1) → N2-{2-[1,3-dihydro-2H-isoindol-2-yl(methyl)amino]-2-oxoethyl}-N2-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-N1-[2-(4-hydroxypiperidin-1-yl)ethyl]glycinamide (1190893-62-9)

Guidance literature:

In N₂-{2-[1,3-dihydro-2H-isoindol-2-yl(methyl)amino]-2-oxoethyl}-N₂-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-N₁-(2-bromoethyl)glycinamide; N,N-dimethyl-formamide;

Reference yield: 86.0%

N2-{2-[1,3-dihydro-2H-isoindol-2-yl(methyl)amino]-2-oxoethyl}-N2-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-N1-[2-(4-hydroxypiperidin-1-yl)ethyl]glycinamide (1190893-62-9) → N2-{2-[1,3-dihydro-2H-isoindol-2-yl(methyl)amino]-2-oxoethyl}-N2-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-N1-[2-(4-hydroxypiperidin-1-yl)ethyl]glycinamide dihydrochloride

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; ethyl acetate; at 0 - 30 ℃;

upstream raw materials:

4-HYDROXYPIPERIDINE

N₂-{2-[1,3-dihydro-2H-isoindol-2-yl(methyl)amino]-2-oxoethyl}-N₂-[2-methyl-5-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]-N₁-(2-bromoethyl)glycinamide

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