tert-butyl (2S,3R,5S)-2-(3,5-dimethoxyphenyl)-5-(2-hydroxyethyl)-1-tosylpyrrolidin-3-ylcarbamate

Base Information

Chemical Name:tert-butyl (2S,3R,5S)-2-(3,5-dimethoxyphenyl)-5-(2-hydroxyethyl)-1-tosylpyrrolidin-3-ylcarbamate
CAS No.:1429516-73-3
Molecular Formula:C₂₆H₃₆N₂O₇S
Molecular Weight:520.647
Hs Code.:

Synonyms:tert-butyl (2S,3R,5S)-2-(3,5-dimethoxyphenyl)-5-(2-hydroxyethyl)-1-tosylpyrrolidin-3-ylcarbamate

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Chemical Property of tert-butyl (2S,3R,5S)-2-(3,5-dimethoxyphenyl)-5-(2-hydroxyethyl)-1-tosylpyrrolidin-3-ylcarbamate

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Technology Process of tert-butyl (2S,3R,5S)-2-(3,5-dimethoxyphenyl)-5-(2-hydroxyethyl)-1-tosylpyrrolidin-3-ylcarbamate

There total 5 articles about tert-butyl (2S,3R,5S)-2-(3,5-dimethoxyphenyl)-5-(2-hydroxyethyl)-1-tosylpyrrolidin-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1429516-72-2
ethyl 2-((2S,4R,5S)-4-(tert-butoxycarbonylamino)-5-(3,5-dimethoxyphenyl)-1-tosylpyrrolidin-2-yl)acetate

: 1429516-73-3
tert-butyl (2S,3R,5S)-2-(3,5-dimethoxyphenyl)-5-(2-hydroxyethyl)-1-tosylpyrrolidin-3-ylcarbamate

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 0.5h;
DOI:10.1021/ol4006129

Reference yield:

: 1429516-69-7
ethyl 2-((2S,4R,5S)-4-amino-5-(3,5-dimethoxyphenyl)-1-tosylpyrrolidin-2-yl)acetate

: 1429516-73-3
tert-butyl (2S,3R,5S)-2-(3,5-dimethoxyphenyl)-5-(2-hydroxyethyl)-1-tosylpyrrolidin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 3 h / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 20 °C

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol4006129

Reference yield:

: C₇H₁₁NO₄

: 1429516-73-3
tert-butyl (2S,3R,5S)-2-(3,5-dimethoxyphenyl)-5-(2-hydroxyethyl)-1-tosylpyrrolidin-3-ylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: C₃₅H₄₇N₃O₂ / toluene / 24 h / 20 °C / Molecular sieve

2: palladium on activated charcoal; hydrogen / methanol

3: triethylamine / dichloromethane / 3 h / 20 °C

4: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 20 °C

With lithium aluminium tetrahydride; palladium on activated charcoal; C₃₅H₄₇N₃O₂; hydrogen; triethylamine; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/ol4006129