dimethyl (S)-[1-(N-acetylamino)-2-oxo-1-{(E)-3-phenyl-2-propenyl}propyl]phosphonate

Base Information

Chemical Name:dimethyl (S)-[1-(N-acetylamino)-2-oxo-1-{(E)-3-phenyl-2-propenyl}propyl]phosphonate
CAS No.:245366-66-9
Molecular Formula:C₁₆H₂₂NO₅P
Molecular Weight:339.328
Hs Code.:

Synonyms:dimethyl (S)-[1-(N-acetylamino)-2-oxo-1-{(E)-3-phenyl-2-propenyl}propyl]phosphonate

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Chemical Property of dimethyl (S)-[1-(N-acetylamino)-2-oxo-1-{(E)-3-phenyl-2-propenyl}propyl]phosphonate

Chemical Property:

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Technology Process of dimethyl (S)-[1-(N-acetylamino)-2-oxo-1-{(E)-3-phenyl-2-propenyl}propyl]phosphonate

There total 1 articles about dimethyl (S)-[1-(N-acetylamino)-2-oxo-1-{(E)-3-phenyl-2-propenyl}propyl]phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 21040-45-9
Cinnamyl acetate

: 170943-24-5
dimethyl (1-acetamido-2-oxopropyl)phosphonate

: 245366-66-9
dimethyl (S)-[1-(N-acetylamino)-2-oxo-1-{(E)-3-phenyl-2-propenyl}propyl]phosphonate

: dimethyl (R)-[1-(N-acetylamino)-2-oxo-1-{(E)-3-phenyl-2-propenyl}propyl]phosphonate

Guidance literature:: With potassium tert-butylate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; [Pd(?-allyl)(cod)]BF4; In toluene; at -30 ℃; for 20h; Title compound not separated from byproducts.;
DOI:10.1021/ol990679f

Reference yield:

: 245366-66-9
dimethyl (S)-[1-(N-acetylamino)-2-oxo-1-{(E)-3-phenyl-2-propenyl}propyl]phosphonate

: 245366-72-7
dimethyl (2S,3S)-[1-(N-acetylamino)-2-hydroxy-1-{(E)-3-phenyl-2-propenyl}propyl]phosphonate

: 245366-73-8
dimethyl (2S,3R)-[1-(N-acetylamino)-2-hydroxy-1-{(E)-3-phenyl-2-propenyl}propyl]phosphonate

Guidance literature:: With tetrabutylammonium borohydride; In methanol; at -30 ℃;
DOI:10.1021/ol990679f

Reference yield:

: 245366-66-9
dimethyl (S)-[1-(N-acetylamino)-2-oxo-1-{(E)-3-phenyl-2-propenyl}propyl]phosphonate

: C₁₇H₂₂NO₆P

Guidance literature:: Multi-step reaction with 2 steps

1: NaBH₄ / 2-methyl-propan-2-ol / 50 °C

2: (i-Pr)2NEt / CH₂Cl₂ / 22 h / 20 °C

With sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; tert-butyl alcohol;
DOI:10.1021/ol990679f