4-(4-Chloro-butyl)-1-methyl-4-phenyl-1,2,3,4-tetrahydro-pyridine

Base Information

• Chemical Name: 4-(4-Chloro-butyl)-1-methyl-4-phenyl-1,2,3,4-tetrahydro-pyridine
• CAS No.: 74904-10-2
• Molecular Formula: C₁₆H₂₂ClN
• Molecular Weight: 263.81
• Mol file: 74904-10-2.mol

Synonyms:4-(4-Chloro-butyl)-1-methyl-4-phenyl-1,2,3,4-tetrahydro-pyridine

Chemical Property of 4-(4-Chloro-butyl)-1-methyl-4-phenyl-1,2,3,4-tetrahydro-pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-Chloro-butyl)-1-methyl-4-phenyl-1,2,3,4-tetrahydro-pyridine

There total 1 articles about 4-(4-Chloro-butyl)-1-methyl-4-phenyl-1,2,3,4-tetrahydro-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chlorobutyl bromide (6940-78-9) + 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (28289-54-5) → 4-(4-Chloro-butyl)-1-methyl-4-phenyl-1,2,3,4-tetrahydro-pyridine (74904-10-2)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1) THF, -10 deg C; 2) -50 deg C, 10 min;

DOI:10.1021/ja00538a065

Reference yield:

4-(4-Chloro-butyl)-1-methyl-4-phenyl-1,2,3,4-tetrahydro-pyridine (74904-10-2) → cis-2-methyl-4a-phenyldecahydroisoquinoline (50790-97-1,51604-97-8,51605-10-8,51605-11-9,51993-73-8,59227-13-3,76954-43-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NaI / acetonitrile / 24 h / Heating

2: hydrogen / platinum oxide / acetic acid / 15 h / 60 °C / 3102.9 Torr

With hydrogen; sodium iodide; platinum(IV) oxide; In acetic acid; acetonitrile;

DOI:10.1021/ja00538a065

Reference yield:

4-(4-Chloro-butyl)-1-methyl-4-phenyl-1,2,3,4-tetrahydro-pyridine (74904-10-2) → 2-methyl-4a-phenyl-trans-decahydroisoquinoline (50790-97-1,51604-97-8,51605-10-8,51605-11-9,51993-73-8,59227-13-3,76954-43-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NaI / acetonitrile / 24 h / Heating

2: hydrogen / platinum oxide / ethanol / 4 h / 25 °C / 3102.9 Torr

With hydrogen; sodium iodide; platinum(IV) oxide; In ethanol; acetonitrile;

DOI:10.1021/ja00538a065

upstream raw materials:

4-chlorobutyl bromide

1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine

Downstream raw materials:

2-Methyl-4a-phenyl-2,3,4,4a,5,6,7,8-octahydro-isoquinoline

cis-2-methyl-4a-phenyldecahydroisoquinoline

2-methyl-4a-phenyl-trans-decahydroisoquinoline