Technology Process of (R)-3-(2-(benzylthio)-2-oxoethyl)-5-methylhexanoic acid
There total 1 articles about (R)-3-(2-(benzylthio)-2-oxoethyl)-5-methylhexanoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-((1R,2R)-2-(dimethylamino)-1-(4-nitrophenyl)-3-(trityloxy)propyl)-3,5-bis(trifluoromethyl)benzene-sulfonamide;
In
tert-butyl methyl ether;
at -20 ℃;
enantioselective reaction;
Inert atmosphere;
Schlenk technique;
DOI:10.1002/ejoc.201300464
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine; diphenyl phosphoryl azide / toluene / 20 - 90 °C / Inert atmosphere; Schlenk technique
2.1: toluene / Reflux; Inert atmosphere; Schlenk technique
3.1: lithium hydroxide; dihydrogen peroxide / water; tetrahydrofuran / 3 h / 20 °C / Inert atmosphere; Schlenk technique
3.2: 0 °C / Inert atmosphere; Schlenk technique
4.1: palladium on activated charcoal; hydrogen / methanol / 15 h / 20 °C / 11251.1 Torr
With
diphenyl phosphoryl azide; palladium on activated charcoal; hydrogen; dihydrogen peroxide; triethylamine; lithium hydroxide;
In
tetrahydrofuran; methanol; water; toluene;
1.1: |Curtius Rearrangement;
DOI:10.1002/ejoc.201300464
- Guidance literature:
-
With
diphenyl phosphoryl azide; triethylamine;
In
toluene;
at 20 - 90 ℃;
Inert atmosphere;
Schlenk technique;
DOI:10.1002/ejoc.201300464
