1-(tert-butoxycarbonyl)-2-[(4-cyano-3-fluorophenyl)ethynyl]-1H-indole-6-carbonitrile

Base Information

Chemical Name:1-(tert-butoxycarbonyl)-2-[(4-cyano-3-fluorophenyl)ethynyl]-1H-indole-6-carbonitrile
CAS No.:1214278-94-0
Molecular Formula:C₂₃H₁₆FN₃O₂
Molecular Weight:385.397
Hs Code.:

Synonyms:1-(tert-butoxycarbonyl)-2-[(4-cyano-3-fluorophenyl)ethynyl]-1H-indole-6-carbonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(tert-butoxycarbonyl)-2-[(4-cyano-3-fluorophenyl)ethynyl]-1H-indole-6-carbonitrile

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Technology Process of 1-(tert-butoxycarbonyl)-2-[(4-cyano-3-fluorophenyl)ethynyl]-1H-indole-6-carbonitrile

There total 1 articles about 1-(tert-butoxycarbonyl)-2-[(4-cyano-3-fluorophenyl)ethynyl]-1H-indole-6-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 167858-57-3
4-ethynyl-2-fluorobenzonitrile

: 1214278-83-7
1-(tert-butoxycarbonyl)-2-iodo-1H-indole-6-carbonitrile

: 1214278-94-0
1-(tert-butoxycarbonyl)-2-[(4-cyano-3-fluorophenyl)ethynyl]-1H-indole-6-carbonitrile

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.bmc.2009.12.011

Reference yield: 51.0%

: 1214278-94-0
1-(tert-butoxycarbonyl)-2-[(4-cyano-3-fluorophenyl)ethynyl]-1H-indole-6-carbonitrile

: 2-[(4-amidino-3-fluorophenyl)ethynyl]-6-amidino-1H-indole dihydrochloride

Guidance literature:: 1-(tert-butoxycarbonyl)-2-[(4-cyano-3-fluorophenyl)ethynyl]-1H-indole-6-carbonitrile; With lithium hexamethyldisilazane; In tetrahydrofuran; at 20 ℃; for 72h;

With hydrogenchloride; In tetrahydrofuran; ethanol; at 0 ℃; Further stages;
DOI:10.1016/j.bmc.2009.12.011