5'-O-(4,4'-dimethoxytrityl)-N⁶-(9-fluorenylmethoxycarbonyl)-2'-deoxyadenosine-3'-O-(methyl N,N-diisopropylamino)phosphoramidite

Base Information

• Chemical Name: 5'-O-(4,4'-dimethoxytrityl)-N⁶-(9-fluorenylmethoxycarbonyl)-2'-deoxyadenosine-3'-O-(methyl N,N-diisopropylamino)phosphoramidite
• CAS No.: 127845-03-8
• Molecular Formula: C₅₃H₅₇N₆O₈P
• Molecular Weight: 937.045

Synonyms:5'-O-(4,4'-dimethoxytrityl)-N⁶-(9-fluorenylmethoxycarbonyl)-2'-deoxyadenosine-3'-O-(methyl N,N-diisopropylamino)phosphoramidite

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-N⁶-(9-fluorenylmethoxycarbonyl)-2'-deoxyadenosine-3'-O-(methyl N,N-diisopropylamino)phosphoramidite

Chemical Property:

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-N⁶-(9-fluorenylmethoxycarbonyl)-2'-deoxyadenosine-3'-O-(methyl N,N-diisopropylamino)phosphoramidite

There total 3 articles about 5'-O-(4,4'-dimethoxytrityl)-N⁶-(9-fluorenylmethoxycarbonyl)-2'-deoxyadenosine-3'-O-(methyl N,N-diisopropylamino)phosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

N,N-diisopropylmethylphosphonamidic chloride (86030-43-5) + 2'-deoxy-5'-O-(dimethoxytrityl)-N6-[(9H-fluoren-9-ylmethoxy)carbonyl]adenosine (109389-32-4) → 5'-O-(4,4'-dimethoxytrityl)-N6-(9-fluorenylmethoxycarbonyl)-2'-deoxyadenosine-3'-O-(methyl N,N-diisopropylamino)phosphoramidite (127845-03-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.5h;

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 5'-O-(4,4'-dimethoxytrityl)-N6-(9-fluorenylmethoxycarbonyl)-2'-deoxyadenosine-3'-O-(methyl N,N-diisopropylamino)phosphoramidite (127845-03-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / pyridine / 6 h / Ambient temperature

2: 87 percent / diisopropylethylamine / CH₂Cl₂ / 0.5 h / 0 °C

With pyridine; N-ethyl-N,N-diisopropylamine; In dichloromethane;

Reference yield:

2'-deoxy-N6-[(9H-fluoren-9-ylmethoxy)carbonyl]adenosine (87424-20-2) → 5'-O-(4,4'-dimethoxytrityl)-N6-(9-fluorenylmethoxycarbonyl)-2'-deoxyadenosine-3'-O-(methyl N,N-diisopropylamino)phosphoramidite (127845-03-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / pyridine / 6 h / Ambient temperature

2: 87 percent / diisopropylethylamine / CH₂Cl₂ / 0.5 h / 0 °C

With pyridine; N-ethyl-N,N-diisopropylamine; In dichloromethane;

upstream raw materials:

N,N-diisopropylmethylphosphonamidic chloride

2'-deoxy-5'-O-(dimethoxytrityl)-N⁶-[(9H-fluoren-9-ylmethoxy)carbonyl]adenosine

4,4'-dimethoxytrityl chloride

2'-deoxy-N⁶-[(9H-fluoren-9-ylmethoxy)carbonyl]adenosine

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