N-(2,6-dichlorobenzoyl)-4-(2,6-dimethoxyphenyl)-L-phenylalanine methyl ester

Base Information

• Chemical Name: N-(2,6-dichlorobenzoyl)-4-(2,6-dimethoxyphenyl)-L-phenylalanine methyl ester
• CAS No.: 232275-99-9
• Molecular Formula: C₂₅H₂₃Cl₂NO₅
• Molecular Weight: 488.367
• Mol file: 232275-99-9.mol

Synonyms:N-(2,6-dichlorobenzoyl)-4-(2,6-dimethoxyphenyl)-L-phenylalanine methyl ester

Chemical Property of N-(2,6-dichlorobenzoyl)-4-(2,6-dimethoxyphenyl)-L-phenylalanine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2,6-dichlorobenzoyl)-4-(2,6-dimethoxyphenyl)-L-phenylalanine methyl ester

There total 7 articles about N-(2,6-dichlorobenzoyl)-4-(2,6-dimethoxyphenyl)-L-phenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

(2,6-dimethoxyphenyl)boronic acid (23112-96-1) + N-(2,6-dichlorobenzoyl)-4-bromo-L-phenylalanine methyl ester (232277-15-5) → N-(2,6-dichlorobenzoyl)-4-(2,6-dimethoxyphenyl)-L-phenylalanine methyl ester (232275-99-9)

Guidance literature:

With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; at 80 ℃; for 6h;

DOI:10.1016/S0968-0896(02)00021-4

Reference yield:

N-(2,6-dichlorobenzoyl)-4-bromo-L-phenylalanine methyl ester (232277-15-5) → N-(2,6-dichlorobenzoyl)-4-(2,6-dimethoxyphenyl)-L-phenylalanine methyl ester (232275-99-9)

Guidance literature:

With potassium carbonate; Pd(Ph₃P)4; In 1,2-dimethoxyethane; water; ethyl acetate;

Reference yield:

H-p-BrPhe-OH (24250-84-8) → N-(2,6-dichlorobenzoyl)-4-(2,6-dimethoxyphenyl)-L-phenylalanine methyl ester (232275-99-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 5.54 g / HCl / 20 °C

2: 3.9 g / Et₃N / CH₂Cl₂ / 20 °C

3: 59 percent / K₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane / 6 h / 80 °C

With hydrogenchloride; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; 3: Suzuki coupling reaction;

DOI:10.1016/S0968-0896(02)00021-4

upstream raw materials:

(2,6-dimethoxyphenyl)boronic acid

N-(2,6-dichlorobenzoyl)-4-bromo-L-phenylalanine methyl ester

H-p-BrPhe-OH

2,6-Dichlorobenzoyl chloride

Downstream raw materials:

N-(2,6-dichlorothiobenzoyl)-4-(2,6-dimethoxyphenyl)-L-phenylalanine methyl ester

N-(2,6-dichlorobenzoyl)-4-(2,6-dimethoxy-3-fluorophenyl)-L-phenylalanine methyl ester

N-(2,6-dichlorobenzoyl)-4-(3-amino-2,6-dimethoxyphenyl)-L-phenylalanine methyl ester

N-(2,6-dichlorobenzoyl)-4-(2,6-dimethoxy-3-nitrophenyl)-L-phenylalanine methyl ester