(S)-di-tert-butyl (3-(4-(5-(4-isopropyl-2-oxooxazolidin-3-yl)pyrazolo[1,5-a]pyrimidin-3-yl)phenyl)-1H-1,2,4-triazol-1-yl)methyl phosphate

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Chemical Name:(S)-di-tert-butyl (3-(4-(5-(4-isopropyl-2-oxooxazolidin-3-yl)pyrazolo[1,5-a]pyrimidin-3-yl)phenyl)-1H-1,2,4-triazol-1-yl)methyl phosphate
CAS No.:1269646-70-9
Molecular Formula:C₂₉H₃₈N₇O₆P
Molecular Weight:611.638
Hs Code.:

Synonyms:(S)-di-tert-butyl (3-(4-(5-(4-isopropyl-2-oxooxazolidin-3-yl)pyrazolo[1,5-a]pyrimidin-3-yl)phenyl)-1H-1,2,4-triazol-1-yl)methyl phosphate

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Chemical Property of (S)-di-tert-butyl (3-(4-(5-(4-isopropyl-2-oxooxazolidin-3-yl)pyrazolo[1,5-a]pyrimidin-3-yl)phenyl)-1H-1,2,4-triazol-1-yl)methyl phosphate

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Technology Process of (S)-di-tert-butyl (3-(4-(5-(4-isopropyl-2-oxooxazolidin-3-yl)pyrazolo[1,5-a]pyrimidin-3-yl)phenyl)-1H-1,2,4-triazol-1-yl)methyl phosphate

There total 8 articles about (S)-di-tert-butyl (3-(4-(5-(4-isopropyl-2-oxooxazolidin-3-yl)pyrazolo[1,5-a]pyrimidin-3-yl)phenyl)-1H-1,2,4-triazol-1-yl)methyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1269643-44-8
(S)-3-(3-(4-(1H-1,2,4-triazol-3-yl)phenyl)pyrazolo[1,5-a]pyrimidin-5-yl)-4-isopropyloxazolidin-2-one

: 229625-50-7
di-tert-butyl chloromethyl phosphate

: 1269646-70-9
(S)-di-tert-butyl (3-(4-(5-(4-isopropyl-2-oxooxazolidin-3-yl)pyrazolo[1,5-a]pyrimidin-3-yl)phenyl)-1H-1,2,4-triazol-1-yl)methyl phosphate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

Reference yield:

: 29274-24-6
5-chloropyrazolo[1,5-a]pyrimidine

: 1269646-70-9
(S)-di-tert-butyl (3-(4-(5-(4-isopropyl-2-oxooxazolidin-3-yl)pyrazolo[1,5-a]pyrimidin-3-yl)phenyl)-1H-1,2,4-triazol-1-yl)methyl phosphate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-Bromosuccinimide / dichloromethane / 1 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 12 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.2: 2.25 h / 0 - 20 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

With N-Bromosuccinimide; sodium hydride; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 698-67-9
p-bromobenzamide

: 1269646-70-9
(S)-di-tert-butyl (3-(4-(5-(4-isopropyl-2-oxooxazolidin-3-yl)pyrazolo[1,5-a]pyrimidin-3-yl)phenyl)-1H-1,2,4-triazol-1-yl)methyl phosphate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1.5 h / 122 °C

2.1: acetic acid; hydrazine hydrate / 1.5 h / 90 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.2: 2.25 h / 0 - 20 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

With hydrazine hydrate; sodium hydride; caesium carbonate; acetic acid; In N,N-dimethyl-formamide;