[4-(1-benzenesulfonyl-piperidin-4-yl)-6-fluoro-naphthalen-2-yl]-acetic acid

Base Information

Chemical Name:[4-(1-benzenesulfonyl-piperidin-4-yl)-6-fluoro-naphthalen-2-yl]-acetic acid
CAS No.:1443042-97-4
Molecular Formula:C₂₃H₂₂FNO₄S
Molecular Weight:427.496
Hs Code.:

Synonyms:[4-(1-benzenesulfonyl-piperidin-4-yl)-6-fluoro-naphthalen-2-yl]-acetic acid

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Chemical Property of [4-(1-benzenesulfonyl-piperidin-4-yl)-6-fluoro-naphthalen-2-yl]-acetic acid

Chemical Property:

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Technology Process of [4-(1-benzenesulfonyl-piperidin-4-yl)-6-fluoro-naphthalen-2-yl]-acetic acid

There total 16 articles about [4-(1-benzenesulfonyl-piperidin-4-yl)-6-fluoro-naphthalen-2-yl]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1443042-98-5
[4-(1-benzenesulfonyl-piperidin-4-yl)-6-fluoro-naphthalen-2-yl]-acetic acid methyl ester

: 1443042-97-4
[4-(1-benzenesulfonyl-piperidin-4-yl)-6-fluoro-naphthalen-2-yl]-acetic acid

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 24h;

Reference yield:

: 1368871-81-1
6-fluoro-4-hydroxy-naphthalene-2-carboxylic acid

: 1443042-97-4
[4-(1-benzenesulfonyl-piperidin-4-yl)-6-fluoro-naphthalen-2-yl]-acetic acid

Guidance literature:: Multi-step reaction with 12 steps

1: thionyl chloride / 5 h / 0 °C / Reflux

2: potassium carbonate; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide; ethyl acetate

3: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

4: triphenylphosphine; tetrachloromethane / tetrahydrofuran / 2 h / Inert atmosphere; Reflux

5: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 20 °C / Inert atmosphere

6: palladium 10% on activated carbon; hydrogen / methanol

7: pyridine / dichloromethane / 2 h / 0 °C

8: potassium carbonate / methanol; dichloromethane / 12 h / Inert atmosphere; Reflux

9: palladium 10% on activated carbon; hydrogen / ethanol / 16 h / 3102.97 Torr

10: dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

11: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

12: lithium hydroxide monohydrate; water / tetrahydrofuran / 24 h / 20 °C

With pyridine; tetrachloromethane; bis-triphenylphosphine-palladium(II) chloride; lithium aluminium tetrahydride; thionyl chloride; lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1227258-79-8
6-fluoro-4-hydroxy-naphthalene-2-carboxylic acid methyl ester

: 1443042-97-4
[4-(1-benzenesulfonyl-piperidin-4-yl)-6-fluoro-naphthalen-2-yl]-acetic acid

Guidance literature:: Multi-step reaction with 11 steps

1: potassium carbonate; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide; ethyl acetate

2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C / Inert atmosphere

3: triphenylphosphine; tetrachloromethane / tetrahydrofuran / 2 h / Inert atmosphere; Reflux

4: potassium carbonate; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran / 20 °C / Inert atmosphere

5: palladium 10% on activated carbon; hydrogen / methanol

6: pyridine / dichloromethane / 2 h / 0 °C

7: potassium carbonate / methanol; dichloromethane / 12 h / Inert atmosphere; Reflux

8: palladium 10% on activated carbon; hydrogen / ethanol / 16 h / 3102.97 Torr

9: dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

10: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

11: lithium hydroxide monohydrate; water / tetrahydrofuran / 24 h / 20 °C

With pyridine; tetrachloromethane; bis-triphenylphosphine-palladium(II) chloride; lithium aluminium tetrahydride; lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;