Technology Process of (3R,4S,6S,9aS)-(-)-4-{[(2,2-dimethylethyl)diphenylsiloxy]methyl}-3-hydroxy-6-(phenylsulfonylmethyl)-octahydro-2H-quinolizine
There total 8 articles about (3R,4S,6S,9aS)-(-)-4-{[(2,2-dimethylethyl)diphenylsiloxy]methyl}-3-hydroxy-6-(phenylsulfonylmethyl)-octahydro-2H-quinolizine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1) Swern reagent, 2) NaH / 2) THF
2: 94 percent / NH4OAc / 10percent Cd-Pb / tetrahydrofuran / 48 h / Ambient temperature
3: 1) 10 percent HCl, 2) imidazole / 1) EtOH, reflux, 2) DMF, 80 deg C
With
1H-imidazole; hydrogenchloride; swern reagent; ammonium acetate; sodium hydride;
10% Cd/Pd;
In
tetrahydrofuran;
DOI:10.1021/jo9608174
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1) H2, 2) LiAlH4, 3) K2CO3 / 1) Pd(OH)2 / 1) EtOH, 2) THF, reflux, 3) CHCl3, H2O
2: 1) Swern reagent, 2) NaH / 2) THF
3: 94 percent / NH4OAc / 10percent Cd-Pb / tetrahydrofuran / 48 h / Ambient temperature
4: 1) 10 percent HCl, 2) imidazole / 1) EtOH, reflux, 2) DMF, 80 deg C
With
1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; swern reagent; ammonium acetate; hydrogen; sodium hydride; potassium carbonate;
palladium dihydroxide; 10% Cd/Pd;
In
tetrahydrofuran;
DOI:10.1021/jo9608174
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1) Swern reagent, 2) NaH / 2) THF
2: 1) H2, 2) LiAlH4, 3) K2CO3 / 1) Pd(OH)2 / 1) EtOH, 2) THF, reflux, 3) CHCl3, H2O
3: 1) Swern reagent, 2) NaH / 2) THF
4: 94 percent / NH4OAc / 10percent Cd-Pb / tetrahydrofuran / 48 h / Ambient temperature
5: 1) 10 percent HCl, 2) imidazole / 1) EtOH, reflux, 2) DMF, 80 deg C
With
1H-imidazole; hydrogenchloride; lithium aluminium tetrahydride; swern reagent; ammonium acetate; hydrogen; sodium hydride; potassium carbonate;
palladium dihydroxide; 10% Cd/Pd;
In
tetrahydrofuran;
DOI:10.1021/jo9608174
