(S)-methyl 2-butyl-1-{[4-({2-[2-(carbomethoxy)-1H-pyrrol-1-yl]-1-oxo-3-phenylpropyl}amino)phenyl]methyl}-1H-imidazole-5-carboxylate

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Chemical Name:(S)-methyl 2-butyl-1-{[4-({2-[2-(carbomethoxy)-1H-pyrrol-1-yl]-1-oxo-3-phenylpropyl}amino)phenyl]methyl}-1H-imidazole-5-carboxylate
CAS No.:148549-77-3
Molecular Formula:C₃₁H₃₄N₄O₅
Molecular Weight:542.635
Hs Code.:

Synonyms:(S)-methyl 2-butyl-1-{[4-({2-[2-(carbomethoxy)-1H-pyrrol-1-yl]-1-oxo-3-phenylpropyl}amino)phenyl]methyl}-1H-imidazole-5-carboxylate

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Chemical Property of (S)-methyl 2-butyl-1-{[4-({2-[2-(carbomethoxy)-1H-pyrrol-1-yl]-1-oxo-3-phenylpropyl}amino)phenyl]methyl}-1H-imidazole-5-carboxylate

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Technology Process of (S)-methyl 2-butyl-1-{[4-({2-[2-(carbomethoxy)-1H-pyrrol-1-yl]-1-oxo-3-phenylpropyl}amino)phenyl]methyl}-1H-imidazole-5-carboxylate

There total 8 articles about (S)-methyl 2-butyl-1-{[4-({2-[2-(carbomethoxy)-1H-pyrrol-1-yl]-1-oxo-3-phenylpropyl}amino)phenyl]methyl}-1H-imidazole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 142219-28-1
(S) Methyl 2-butyl-4-chloro-1-[[4-[[2-[2-(methoxycarbonyl)-1H-pyrrol-1-yl]-1 oxo-3-phenylpropyl]amino]phenyl]methyl]-1H-imidazole-5-carboxylate

: 148549-77-3
(S)-methyl 2-butyl-1-{[4-({2-[2-(carbomethoxy)-1H-pyrrol-1-yl]-1-oxo-3-phenylpropyl}amino)phenyl]methyl}-1H-imidazole-5-carboxylate

Guidance literature:: With hydrogen; potassium acetate; palladium on activated charcoal; In tetrahydrofuran; methanol; for 20h; under 827.4 Torr;
DOI:10.1021/jm00064a007

Reference yield:

: 39658-49-6
2,5-dimethoxy-tetrahydro-furan-2-carboxylic acid methyl ester

: 148549-77-3
(S)-methyl 2-butyl-1-{[4-({2-[2-(carbomethoxy)-1H-pyrrol-1-yl]-1-oxo-3-phenylpropyl}amino)phenyl]methyl}-1H-imidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 41 percent / NaOAc, HOAc / 0.5 h / Heating

2: (CH₃)3CCOCl, DMAP / tetrahydrofuran

3: 67 percent / H₂, potassium acetate / 5 percent Pd/C / tetrahydrofuran; methanol / 20 h / 827.4 Torr

With dmap; hydrogen; potassium acetate; sodium acetate; pivaloyl chloride; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm00064a007

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 148549-77-3
(S)-methyl 2-butyl-1-{[4-({2-[2-(carbomethoxy)-1H-pyrrol-1-yl]-1-oxo-3-phenylpropyl}amino)phenyl]methyl}-1H-imidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 41 percent / NaOAc, HOAc / 0.5 h / Heating

2: (CH₃)3CCOCl, DMAP / tetrahydrofuran

3: 67 percent / H₂, potassium acetate / 5 percent Pd/C / tetrahydrofuran; methanol / 20 h / 827.4 Torr

With dmap; hydrogen; potassium acetate; sodium acetate; pivaloyl chloride; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol;
DOI:10.1021/jm00064a007