N-(2-fluorophenyl)-2-[(2-oxo-3-(4-methoxyphenyl)-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thio]-acetamide

Base Information

• Chemical Name: N-(2-fluorophenyl)-2-[(2-oxo-3-(4-methoxyphenyl)-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thio]-acetamide
• CAS No.: 1412494-09-7
• Molecular Formula: C₂₅H₁₈FN₅O₃S
• Molecular Weight: 487.514

Synonyms:N-(2-fluorophenyl)-2-[(2-oxo-3-(4-methoxyphenyl)-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thio]-acetamide

Chemical Property of N-(2-fluorophenyl)-2-[(2-oxo-3-(4-methoxyphenyl)-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thio]-acetamide

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Technology Process of N-(2-fluorophenyl)-2-[(2-oxo-3-(4-methoxyphenyl)-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thio]-acetamide

There total 3 articles about N-(2-fluorophenyl)-2-[(2-oxo-3-(4-methoxyphenyl)-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thio]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.4%

2-Fluoroaniline (348-54-9) + C19H14N4O4S (1258381-20-2) → N-(2-fluorophenyl)-2-[(2-oxo-3-(4-methoxyphenyl)-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thio]-acetamide (1412494-09-7)

Guidance literature:

C₁₉H₁₄N₄O₄S; With 1,1'-carbonyldiimidazole; In 1,4-dioxane; at 60 - 80 ℃; for 1h; Reflux;

2-Fluoroaniline; In 1,4-dioxane; for 3 - 6h; Reflux;

DOI:10.1007/s00044-012-0257-x

Reference yield: 75.9%

C17H11N4O2S(1-)*K(1+) (1258381-14-4) + 2-chloro-N-(2-fluorophenyl)acetamide (347-66-0) → N-(2-fluorophenyl)-2-[(2-oxo-3-(4-methoxyphenyl)-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thio]-acetamide (1412494-09-7)

Guidance literature:

In isopropyl alcohol; for 1 - 1.5h; Reflux;

DOI:10.1007/s00044-012-0257-x

Reference yield:

2-Fluoroaniline (348-54-9) + C19H13ClN4O3S → N-(2-fluorophenyl)-2-[(2-oxo-3-(4-methoxyphenyl)-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thio]-acetamide (1412494-09-7)

Guidance literature:

In 1,4-dioxane; for 3 - 6h; Reflux;

DOI:10.1007/s00044-012-0257-x

upstream raw materials:

2-Fluoroaniline

C₁₉H₁₄N₄O₄S

C₁₇H₁₁N₄O₂S^(1-)*K⁽¹⁺⁾

2-chloro-N-(2-fluorophenyl)acetamide

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