4-(4-methoxyphenyl)-3-(4-nitrophenyl)pyrrole-2-carboxylic acid

Base Information

• Chemical Name: 4-(4-methoxyphenyl)-3-(4-nitrophenyl)pyrrole-2-carboxylic acid
• CAS No.: 1567951-64-7
• Molecular Formula: C₁₈H₁₄N₂O₅
• Molecular Weight: 338.32
• Mol file: 1567951-64-7.mol

Synonyms:4-(4-methoxyphenyl)-3-(4-nitrophenyl)pyrrole-2-carboxylic acid

Chemical Property of 4-(4-methoxyphenyl)-3-(4-nitrophenyl)pyrrole-2-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(4-methoxyphenyl)-3-(4-nitrophenyl)pyrrole-2-carboxylic acid

There total 4 articles about 4-(4-methoxyphenyl)-3-(4-nitrophenyl)pyrrole-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

ethyl 4-(4-methoxyphenyl)-3-(4-nitrophenyl)pyrrole-2-carboxylate → 4-(4-methoxyphenyl)-3-(4-nitrophenyl)pyrrole-2-carboxylic acid (1567951-64-7)

Guidance literature:

With sodium hydroxide; In ethanol; water; Reflux;

DOI:10.1007/s11172-018-2150-3

Reference yield: 83.0%

C17H18N2O3 + 3-(4-nitrophenyl)-2-oxopropanoic acid (38335-24-9) → 4-(4-methoxyphenyl)-3-(4-nitrophenyl)pyrrole-2-carboxylic acid (1567951-64-7)

Guidance literature:

With acetic acid; In ethanol; at 70 ℃; for 2h; Inert atmosphere;

DOI:10.1039/c3cc49724k

Reference yield:

(E)-4-(2-bromo-vinyl)-anisole (6303-59-9,60592-52-1,27570-08-7) → 4-(4-methoxyphenyl)-3-(4-nitrophenyl)pyrrole-2-carboxylic acid (1567951-64-7)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) iodide; caesium carbonate / dimethyl sulfoxide / 2 h / 80 °C / Inert atmosphere

2: acetic acid / ethanol / 2 h / 70 °C / Inert atmosphere

With copper(l) iodide; caesium carbonate; acetic acid; In ethanol; dimethyl sulfoxide;

DOI:10.1039/c3cc49724k

upstream raw materials:

(E)-4-(2-bromo-vinyl)-anisole

3-(4-nitrophenyl)-2-oxopropanoic acid