(S)-8,8-diethyl-4-oxo-3-propylamino-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic acid 4-carbamimidoyl-benzylamide

Base Information

Chemical Name:(S)-8,8-diethyl-4-oxo-3-propylamino-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic acid 4-carbamimidoyl-benzylamide
CAS No.:639832-38-5
Molecular Formula:C₂₃H₃₂N₆O₂
Molecular Weight:424.546
Hs Code.:

Synonyms:(S)-8,8-diethyl-4-oxo-3-propylamino-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic acid 4-carbamimidoyl-benzylamide

Suppliers and Price of (S)-8,8-diethyl-4-oxo-3-propylamino-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic acid 4-carbamimidoyl-benzylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-8,8-diethyl-4-oxo-3-propylamino-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic acid 4-carbamimidoyl-benzylamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-8,8-diethyl-4-oxo-3-propylamino-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic acid 4-carbamimidoyl-benzylamide

There total 3 articles about (S)-8,8-diethyl-4-oxo-3-propylamino-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic acid 4-carbamimidoyl-benzylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 639832-46-5
(S)-allyl-{6-[4-(benzyloxycarbonylamino-imino-methyl)-benzylcarbamoyl]-8,8-diethyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidin-3-yl}-carbamic acid benzyl ester

: 639832-38-5
(S)-8,8-diethyl-4-oxo-3-propylamino-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic acid 4-carbamimidoyl-benzylamide

Guidance literature:: With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In methanol; water; for 1h;

Reference yield:

: 639832-44-3
(S)-3-(allyl-benzyloxycarbonyl-amino)-8,8-diethyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic Acid

: 147291-50-7,854762-31-5
benzyl ((4-(aminomethyl)phenyl)(imino)methyl)carbamate

: 639832-38-5
(S)-8,8-diethyl-4-oxo-3-propylamino-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic acid 4-carbamimidoyl-benzylamide

Guidance literature:: (S)-3-(allyl-benzyloxycarbonyl-amino)-8,8-diethyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic Acid; benzyl ((4-(aminomethyl)phenyl)(imino)methyl)carbamate; With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;

With palladium on activated charcoal; hydrogen; In methanol;
DOI:10.1016/j.bmcl.2013.01.094

Reference yield:

: 639832-40-9
(S)-allyl-(8,8-diethyl-4-oxo-6-phenylcarbamoyl-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidin-3-yl)-carbamic Acid Benzyl Ester

: 639832-38-5
(S)-8,8-diethyl-4-oxo-3-propylamino-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic acid 4-carbamimidoyl-benzylamide

Guidance literature:: Multi-step reaction with 2 steps

1: tert-butyldicarbonate; dmap

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 1-hydroxy-7-aza-benzotriazole

With dmap; 1-hydroxy-7-aza-benzotriazole; tert-butyldicarbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
DOI:10.1016/j.bmcl.2013.01.094