N-(2-iodophenyl)-4-methoxy-N,9-bis-(methoxymethyl)-9H-carbazole-3-carboxamide

Base Information

Chemical Name:N-(2-iodophenyl)-4-methoxy-N,9-bis-(methoxymethyl)-9H-carbazole-3-carboxamide
CAS No.:1425235-48-8
Molecular Formula:C₂₄H₂₃IN₂O₄
Molecular Weight:530.362
Hs Code.:

Synonyms:N-(2-iodophenyl)-4-methoxy-N,9-bis-(methoxymethyl)-9H-carbazole-3-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-iodophenyl)-4-methoxy-N,9-bis-(methoxymethyl)-9H-carbazole-3-carboxamide

Chemical Property:

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Technology Process of N-(2-iodophenyl)-4-methoxy-N,9-bis-(methoxymethyl)-9H-carbazole-3-carboxamide

There total 5 articles about N-(2-iodophenyl)-4-methoxy-N,9-bis-(methoxymethyl)-9H-carbazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1425235-47-7
N-(2-iodophenyl)-4-methoxy-9H-carbazole-3-carboxamide

: 107-30-2
chloromethyl methyl ether

: 1425235-48-8
N-(2-iodophenyl)-4-methoxy-N,9-bis-(methoxymethyl)-9H-carbazole-3-carboxamide

Guidance literature:: With sodium hydride; In tetrahydrofuran; mineral oil; at 50 ℃; for 20.5h; Cooling with ice; Inert atmosphere;
DOI:10.1021/jo302821v

Reference yield:

: 1425235-45-5
4-methoxy-9H-carbazole-3-carbaldehyde

: 1425235-48-8
N-(2-iodophenyl)-4-methoxy-N,9-bis-(methoxymethyl)-9H-carbazole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: dihydrogen peroxide; potassium dihydrogenphosphate; sodium chlorite / tetrahydrofuran; water / 8 h / 20 °C

2: thionyl chloride / chloroform / 6 h / Reflux

3: potassium carbonate / tetrahydrofuran / 12 h / 20 °C

4: sodium hydride / tetrahydrofuran; mineral oil / 20.5 h / 50 °C / Cooling with ice; Inert atmosphere

With sodium chlorite; potassium dihydrogenphosphate; thionyl chloride; dihydrogen peroxide; sodium hydride; potassium carbonate; In tetrahydrofuran; chloroform; water; mineral oil;
DOI:10.1021/jo302821v

Reference yield:

: 6933-50-2
4-methoxy-9H-carbazole

: 1425235-48-8
N-(2-iodophenyl)-4-methoxy-N,9-bis-(methoxymethyl)-9H-carbazole-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: trichlorophosphate / 1,2-dichloro-benzene / 3 h / 70 °C / Cooling with ice

2: dihydrogen peroxide; potassium dihydrogenphosphate; sodium chlorite / tetrahydrofuran; water / 8 h / 20 °C

3: thionyl chloride / chloroform / 6 h / Reflux

4: potassium carbonate / tetrahydrofuran / 12 h / 20 °C

5: sodium hydride / tetrahydrofuran; mineral oil / 20.5 h / 50 °C / Cooling with ice; Inert atmosphere

With sodium chlorite; potassium dihydrogenphosphate; thionyl chloride; dihydrogen peroxide; sodium hydride; potassium carbonate; trichlorophosphate; In tetrahydrofuran; chloroform; water; 1,2-dichloro-benzene; mineral oil; 1: |Vilsmeier-Haack Formylation;
DOI:10.1021/jo302821v