Toluene-4-sulfonic acid 2-[(1S,2S)-2-[2-cyano-2-(1-ethoxy-ethoxy)-ethyl]-5-eth-(E)-ylidene-1-methyl-cyclopentyl]-ethyl ester

Base Information

Chemical Name:Toluene-4-sulfonic acid 2-[(1S,2S)-2-[2-cyano-2-(1-ethoxy-ethoxy)-ethyl]-5-eth-(E)-ylidene-1-methyl-cyclopentyl]-ethyl ester
CAS No.:79487-72-2
Molecular Formula:C₂₄H₃₅NO₅S
Molecular Weight:449.612
Hs Code.:

Synonyms:Toluene-4-sulfonic acid 2-[(1S,2S)-2-[2-cyano-2-(1-ethoxy-ethoxy)-ethyl]-5-eth-(E)-ylidene-1-methyl-cyclopentyl]-ethyl ester

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Chemical Property of Toluene-4-sulfonic acid 2-[(1S,2S)-2-[2-cyano-2-(1-ethoxy-ethoxy)-ethyl]-5-eth-(E)-ylidene-1-methyl-cyclopentyl]-ethyl ester

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Technology Process of Toluene-4-sulfonic acid 2-[(1S,2S)-2-[2-cyano-2-(1-ethoxy-ethoxy)-ethyl]-5-eth-(E)-ylidene-1-methyl-cyclopentyl]-ethyl ester

There total 24 articles about Toluene-4-sulfonic acid 2-[(1S,2S)-2-[2-cyano-2-(1-ethoxy-ethoxy)-ethyl]-5-eth-(E)-ylidene-1-methyl-cyclopentyl]-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1120-73-6
2-methyl-2-cyclopenten-1-one

: 79487-72-2
Toluene-4-sulfonic acid 2-[(1S,2S)-2-[2-cyano-2-(1-ethoxy-ethoxy)-ethyl]-5-eth-(E)-ylidene-1-methyl-cyclopentyl]-ethyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 2.) aq. HCl / 1.) THF, -78 deg C, 2.) THF, 0 deg C, 10 min

2: 80 percent / sodium borohydride / tetrahydrofuran; H₂O / 0 °C

3: 71 percent / pyridine / Ambient temperature

4: 57 percent / propionic acid / 3 h / 120 °C

5: 70 percent / K₂CO₃ / 3 h / 0 °C

6: 74 percent / Hg(OAc)2

7: collidine / 1 h / 160 °C

8: NaBH₄

9: pyridine

With pyridine; 2,3,5-trimethyl-pyridine; hydrogenchloride; sodium tetrahydroborate; mercury(II) diacetate; potassium carbonate; propionic acid; In tetrahydrofuran; water;
DOI:10.1021/ja00407a062

Reference yield:

: 79487-64-2
1-(1-Hydroxy-2-methyl-cyclopent-2-enyl)-ethanone

: 79487-72-2
Toluene-4-sulfonic acid 2-[(1S,2S)-2-[2-cyano-2-(1-ethoxy-ethoxy)-ethyl]-5-eth-(E)-ylidene-1-methyl-cyclopentyl]-ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 80 percent / sodium borohydride / tetrahydrofuran; H₂O / 0 °C

2: 71 percent / pyridine / Ambient temperature

3: 57 percent / propionic acid / 3 h / 120 °C

4: 70 percent / K₂CO₃ / 3 h / 0 °C

5: 74 percent / Hg(OAc)2

6: collidine / 1 h / 160 °C

7: NaBH₄

8: pyridine

With pyridine; 2,3,5-trimethyl-pyridine; sodium tetrahydroborate; mercury(II) diacetate; potassium carbonate; propionic acid; In tetrahydrofuran; water;
DOI:10.1021/ja00407a062

Reference yield:

: 81794-95-8,81794-96-9
(S)-1-((R)-3-[1,3]Dioxolan-2-ylmethyl-2-methyl-cyclopent-1-enyl)-ethanol

: 79487-72-2
Toluene-4-sulfonic acid 2-[(1S,2S)-2-[2-cyano-2-(1-ethoxy-ethoxy)-ethyl]-5-eth-(E)-ylidene-1-methyl-cyclopentyl]-ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: Hg(OCOCH₃)2

2: 100 percent / various solvent(s) / 1 h / 160 °C

3: NaBH₄

4: pyridine

5: H⁽¹⁺⁾

6: NaHSO₄

7: H⁽¹⁺⁾

With pyridine; sodium tetrahydroborate; sodium hydrogen sulfate; mercury(II) diacetate; hydrogen cation; hydrogen cation; In various solvent(s);
DOI:10.1016/S0040-4039(00)86793-3