N₂-(4-tert-butoxycarbonyl-3,5-dimethyl)phenyl-5-methyl-N₄-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine

Base Information

• Chemical Name: N₂-(4-tert-butoxycarbonyl-3,5-dimethyl)phenyl-5-methyl-N₄-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine
• CAS No.: 1357101-83-7
• Molecular Formula: C₂₅H₂₇N₅O₄
• Molecular Weight: 461.52
• Mol file: 1357101-83-7.mol

Synonyms:N₂-(4-tert-butoxycarbonyl-3,5-dimethyl)phenyl-5-methyl-N₄-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine

Chemical Property of N₂-(4-tert-butoxycarbonyl-3,5-dimethyl)phenyl-5-methyl-N₄-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₂-(4-tert-butoxycarbonyl-3,5-dimethyl)phenyl-5-methyl-N₄-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine

There total 7 articles about N₂-(4-tert-butoxycarbonyl-3,5-dimethyl)phenyl-5-methyl-N₄-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 4-amino-2,6-dimethylbenzoate (306296-73-1) + 2-chloro-5-methyl-N4-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-4-pyrimidineamine (1236670-87-3) → N2-(4-tert-butoxycarbonyl-3,5-dimethyl)phenyl-5-methyl-N4-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine (1357101-83-7)

Guidance literature:

tert-butyl 4-amino-2,6-dimethylbenzoate; 2-chloro-5-methyl-N₄-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-4-pyrimidineamine; With trifluoroacetic acid; In isopropyl alcohol; at 100 ℃; Sealed tube;

With ammonia; In methanol; isopropyl alcohol;

Reference yield:

5-amino-2-benzoxazolinone (14733-77-8) → N2-(4-tert-butoxycarbonyl-3,5-dimethyl)phenyl-5-methyl-N4-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine (1357101-83-7)

Guidance literature:

Multi-step reaction with 2 steps

1: water; methanol / 64 h / 20 °C

2: trifluoroacetic acid / isopropyl alcohol / 100 °C / Sealed tube

With trifluoroacetic acid; In methanol; water; isopropyl alcohol;

Reference yield:

N-(4-bromo-3,5-dimethylphenyl)-2,2,2-trifluoro-acetamide (306297-11-0) → N2-(4-tert-butoxycarbonyl-3,5-dimethyl)phenyl-5-methyl-N4-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine (1357101-83-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: methyllithium / diethyl ether; tetrahydrofuran / -78 °C

1.2: 0.08 h / -78 °C

1.3: 3.5 h / -78 - 20 °C

2.1: sodium hydroxide; water / methanol / 20 - 60 °C

3.1: trifluoroacetic acid / isopropyl alcohol / 100 °C / Sealed tube

With water; methyllithium; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; diethyl ether; isopropyl alcohol;

upstream raw materials:

5-amino-2-benzoxazolinone

3,5-dimethylaminoaniline

N-(4-bromo-3,5-dimethylphenyl)-2,2,2-trifluoro-acetamide

N₁-[4-(tert-butoxy)carbonyl-3,5-dimethylphenyl]-2,2,2-trifluoroacetamide

Downstream raw materials:

N₂-(4-carboxy-3,5-dimethyl)phenyl-5-methyl-N₄-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine

N₂-(3,5-dimethyl-4-hydroxymethyl)phenyl-5-methyl-N₄-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine

N₂-(3,5-dimethyl-4-methoxymethyl)phenyl-5-methyl-N₄-(2-oxo-2,3-dihydro-1,3-benzoxazol-5-yl)-2,4-pyrimidinediamine