Technology Process of 5-Chloro-2-methoxy-4-methylbenzaldehyde
There total 3 articles about 5-Chloro-2-methoxy-4-methylbenzaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
1-chloro-5-iodo-4-methoxy-2-methylbenzene;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 2h;
Inert atmosphere;
N,N-dimethyl-formamide;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 2h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: iron(III)-acetylacetonate; 1,1,3,3-Tetramethyldisiloxane / tetrahydrofuran / 15 h / Reflux; Sealed tube; Inert atmosphere
2.1: hydrogenchloride; acetic acid; sodium nitrite / water / 0.5 h / 0 - 20 °C / Inert atmosphere
2.2: 2 h / 20 °C / Inert atmosphere
3.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere
3.2: 2 h / -78 °C / Inert atmosphere
With
hydrogenchloride; n-butyllithium; iron(III)-acetylacetonate; 1,1,3,3-Tetramethyldisiloxane; acetic acid; sodium nitrite;
In
tetrahydrofuran; hexane; water;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: hydrogenchloride; acetic acid; sodium nitrite / water / 0.5 h / 0 - 20 °C / Inert atmosphere
1.2: 2 h / 20 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere
2.2: 2 h / -78 °C / Inert atmosphere
With
hydrogenchloride; n-butyllithium; acetic acid; sodium nitrite;
In
tetrahydrofuran; hexane; water;
