N-butyl-2-(2-(2-(butylamino)-2-oxoethyl)-4-methylphenyl)-4,7-dimethyl-1-naphthamide

Base Information

Chemical Name:N-butyl-2-(2-(2-(butylamino)-2-oxoethyl)-4-methylphenyl)-4,7-dimethyl-1-naphthamide
CAS No.:1301714-82-8
Molecular Formula:C₃₀H₃₈N₂O₂
Molecular Weight:458.644
Hs Code.:

Synonyms:N-butyl-2-(2-(2-(butylamino)-2-oxoethyl)-4-methylphenyl)-4,7-dimethyl-1-naphthamide

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Chemical Property of N-butyl-2-(2-(2-(butylamino)-2-oxoethyl)-4-methylphenyl)-4,7-dimethyl-1-naphthamide

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Technology Process of N-butyl-2-(2-(2-(butylamino)-2-oxoethyl)-4-methylphenyl)-4,7-dimethyl-1-naphthamide

There total 5 articles about N-butyl-2-(2-(2-(butylamino)-2-oxoethyl)-4-methylphenyl)-4,7-dimethyl-1-naphthamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1301714-68-0
N-butyl-2-(2-ethynyl-5-methylphenyl)acetamide

: 1301714-82-8
N-butyl-2-(2-(2-(butylamino)-2-oxoethyl)-4-methylphenyl)-4,7-dimethyl-1-naphthamide

Guidance literature:: With silver hexafluoroantimonate; (triphenylphosphine)gold(I) chloride; In toluene; at 70 ℃; for 8h; regioselective reaction; Inert atmosphere;
DOI:10.1021/jo200352j

Reference yield:

: 220991-52-6
(2-iodo-5-methyl-phenyl)-acetic acid

: 1301714-82-8
N-butyl-2-(2-(2-(butylamino)-2-oxoethyl)-4-methylphenyl)-4,7-dimethyl-1-naphthamide

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / 2 h / Reflux

2: dichloromethane / 2 h

3: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 70 °C / Inert atmosphere

4: potassium carbonate / methanol; dichloromethane / 2 h / 20 °C

5: (triphenylphosphine)gold(I) chloride; silver hexafluoroantimonate / toluene / 8 h / 70 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; silver hexafluoroantimonate; copper(l) iodide; thionyl chloride; (triphenylphosphine)gold(I) chloride; potassium carbonate; triethylamine; In methanol; dichloromethane; toluene;
DOI:10.1021/jo200352j

Reference yield:

: 5-methyl-2-iodophenylacetyl chloride

: 1301714-82-8
N-butyl-2-(2-(2-(butylamino)-2-oxoethyl)-4-methylphenyl)-4,7-dimethyl-1-naphthamide

Guidance literature:: Multi-step reaction with 4 steps

1: dichloromethane / 2 h

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 70 °C / Inert atmosphere

3: potassium carbonate / methanol; dichloromethane / 2 h / 20 °C

4: (triphenylphosphine)gold(I) chloride; silver hexafluoroantimonate / toluene / 8 h / 70 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; silver hexafluoroantimonate; copper(l) iodide; (triphenylphosphine)gold(I) chloride; potassium carbonate; triethylamine; In methanol; dichloromethane; toluene;
DOI:10.1021/jo200352j