N-butyl-2-(2-(2-(butylamino)-2-oxoethyl)-4-methylphenyl)-4,7-dimethyl-1-naphthamide

Base Information

• Chemical Name: N-butyl-2-(2-(2-(butylamino)-2-oxoethyl)-4-methylphenyl)-4,7-dimethyl-1-naphthamide
• CAS No.: 1301714-82-8
• Molecular Formula: C₃₀H₃₈N₂O₂
• Molecular Weight: 458.644
• Mol file: 1301714-82-8.mol

Synonyms:N-butyl-2-(2-(2-(butylamino)-2-oxoethyl)-4-methylphenyl)-4,7-dimethyl-1-naphthamide

Chemical Property of N-butyl-2-(2-(2-(butylamino)-2-oxoethyl)-4-methylphenyl)-4,7-dimethyl-1-naphthamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-butyl-2-(2-(2-(butylamino)-2-oxoethyl)-4-methylphenyl)-4,7-dimethyl-1-naphthamide

There total 5 articles about N-butyl-2-(2-(2-(butylamino)-2-oxoethyl)-4-methylphenyl)-4,7-dimethyl-1-naphthamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

N-butyl-2-(2-ethynyl-5-methylphenyl)acetamide (1301714-68-0) → N-butyl-2-(2-(2-(butylamino)-2-oxoethyl)-4-methylphenyl)-4,7-dimethyl-1-naphthamide (1301714-82-8)

Guidance literature:

With silver hexafluoroantimonate; (triphenylphosphine)gold(I) chloride; In toluene; at 70 ℃; for 8h; regioselective reaction; Inert atmosphere;

DOI:10.1021/jo200352j

Reference yield:

(2-iodo-5-methyl-phenyl)-acetic acid (220991-52-6) → N-butyl-2-(2-(2-(butylamino)-2-oxoethyl)-4-methylphenyl)-4,7-dimethyl-1-naphthamide (1301714-82-8)

Guidance literature:

Multi-step reaction with 5 steps

1: thionyl chloride / 2 h / Reflux

2: dichloromethane / 2 h

3: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 70 °C / Inert atmosphere

4: potassium carbonate / methanol; dichloromethane / 2 h / 20 °C

5: (triphenylphosphine)gold(I) chloride; silver hexafluoroantimonate / toluene / 8 h / 70 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; silver hexafluoroantimonate; copper(l) iodide; thionyl chloride; (triphenylphosphine)gold(I) chloride; potassium carbonate; triethylamine; In methanol; dichloromethane; toluene;

DOI:10.1021/jo200352j

Reference yield:

5-methyl-2-iodophenylacetyl chloride → N-butyl-2-(2-(2-(butylamino)-2-oxoethyl)-4-methylphenyl)-4,7-dimethyl-1-naphthamide (1301714-82-8)

Guidance literature:

Multi-step reaction with 4 steps

1: dichloromethane / 2 h

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 70 °C / Inert atmosphere

3: potassium carbonate / methanol; dichloromethane / 2 h / 20 °C

4: (triphenylphosphine)gold(I) chloride; silver hexafluoroantimonate / toluene / 8 h / 70 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; silver hexafluoroantimonate; copper(l) iodide; (triphenylphosphine)gold(I) chloride; potassium carbonate; triethylamine; In methanol; dichloromethane; toluene;

DOI:10.1021/jo200352j

upstream raw materials:

(2-iodo-5-methyl-phenyl)-acetic acid

N-butyl-2-(2-ethynyl-5-methylphenyl)acetamide