4-(hydroxyamino)-N-(2-hydroxyethyl)-2-oxo-6-p-tolyl-2H-pyran-3-carboxamide

Base Information

Chemical Name:4-(hydroxyamino)-N-(2-hydroxyethyl)-2-oxo-6-p-tolyl-2H-pyran-3-carboxamide
CAS No.:1512807-75-8
Molecular Formula:C₁₅H₁₆N₂O₅
Molecular Weight:304.302
Hs Code.:

Synonyms:4-(hydroxyamino)-N-(2-hydroxyethyl)-2-oxo-6-p-tolyl-2H-pyran-3-carboxamide

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Chemical Property of 4-(hydroxyamino)-N-(2-hydroxyethyl)-2-oxo-6-p-tolyl-2H-pyran-3-carboxamide

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Technology Process of 4-(hydroxyamino)-N-(2-hydroxyethyl)-2-oxo-6-p-tolyl-2H-pyran-3-carboxamide

There total 3 articles about 4-(hydroxyamino)-N-(2-hydroxyethyl)-2-oxo-6-p-tolyl-2H-pyran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1512808-35-3
N-(2-hydroxyethyl)-4-(methylthio)-2-oxo-6-p-tolyl-2H-pyran-3-carboxamide

: 1512807-75-8
4-(hydroxyamino)-N-(2-hydroxyethyl)-2-oxo-6-p-tolyl-2H-pyran-3-carboxamide

Guidance literature:: With hydroxylamine hydrochloride; sodium hydrogencarbonate; In ethanol; at 80 ℃; for 4h;
DOI:10.1021/ml400432f

Reference yield:

: 41467-27-0
3,3-bis(methylthio)-1-(p-tolyl)prop-2-en-1-one

: 1512807-75-8
4-(hydroxyamino)-N-(2-hydroxyethyl)-2-oxo-6-p-tolyl-2H-pyran-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / 1,4-dioxane / 0.5 h / 0 °C

1.2: 6.5 h / 0 - 110 °C

2.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C

3.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 4 h / 80 °C

With hydroxylamine hydrochloride; sodium hydride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/ml400432f

Reference yield:

: 127449-57-4
C₁₄H₁₂O₄S

: 1512807-75-8
4-(hydroxyamino)-N-(2-hydroxyethyl)-2-oxo-6-p-tolyl-2H-pyran-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 20 °C

2: hydroxylamine hydrochloride; sodium hydrogencarbonate / ethanol / 4 h / 80 °C

With hydroxylamine hydrochloride; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/ml400432f