2,2'-[1-(diphenylphosphinomethyl)ethylidene]-bis[(4S)-4-isopropyl-4,5-dihydro-oxazole]

Base Information

Chemical Name:2,2'-[1-(diphenylphosphinomethyl)ethylidene]-bis[(4S)-4-isopropyl-4,5-dihydro-oxazole]
CAS No.:863297-39-6
Molecular Formula:C₂₇H₃₅N₂O₂P
Molecular Weight:450.561
Hs Code.:

Synonyms:2,2'-[1-(diphenylphosphinomethyl)ethylidene]-bis[(4S)-4-isopropyl-4,5-dihydro-oxazole]

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2,2'-[1-(diphenylphosphinomethyl)ethylidene]-bis[(4S)-4-isopropyl-4,5-dihydro-oxazole]

Chemical Property:

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Technology Process of 2,2'-[1-(diphenylphosphinomethyl)ethylidene]-bis[(4S)-4-isopropyl-4,5-dihydro-oxazole]

There total 3 articles about 2,2'-[1-(diphenylphosphinomethyl)ethylidene]-bis[(4S)-4-isopropyl-4,5-dihydro-oxazole] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1315454-22-8
2,2'-(1-bromomethylethylidene)bis[(4S)-4-isopropyl-4,5-dihydro-oxazole]

: 15475-27-1,4346-39-8
potassium diphenylphosphine

: 863297-39-6
2,2'-[1-(diphenylphosphinomethyl)ethylidene]-bis[(4S)-4-isopropyl-4,5-dihydro-oxazole]

Guidance literature:: In tetrahydrofuran; at 0 ℃; for 1h;
DOI:10.1016/j.tet.2011.05.079

Reference yield:

: 131833-90-4,152754-11-5
2,2'-methylenebis[(4S)-4-isopropyl-4,5-dihydro-oxazole]

: 863297-39-6
2,2'-[1-(diphenylphosphinomethyl)ethylidene]-bis[(4S)-4-isopropyl-4,5-dihydro-oxazole]

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

1.2: 4 h / Inert atmosphere; Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

2.2: 4 h / Inert atmosphere; Reflux

3.1: tetrahydrofuran / 1 h / 0 °C

With n-butyllithium; potassium tert-butylate; In tetrahydrofuran; hexane;
DOI:10.1016/j.tet.2011.05.079

Reference yield:

: 499786-37-7
1,1‐bis[(4S)‐4‐isopropyl‐4,5‐dihydrooxazol‐2‐yl]ethane

: 863297-39-6
2,2'-[1-(diphenylphosphinomethyl)ethylidene]-bis[(4S)-4-isopropyl-4,5-dihydro-oxazole]

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

1.2: 4 h / Inert atmosphere; Reflux

2.1: tetrahydrofuran / 1 h / 0 °C

With n-butyllithium; In tetrahydrofuran; hexane;
DOI:10.1016/j.tet.2011.05.079