Technology Process of 4-(1-azi-2,2,2-trifluoroethyl)-1-(2-bromoethoxy)-2-nitrobenzene
There total 9 articles about 4-(1-azi-2,2,2-trifluoroethyl)-1-(2-bromoethoxy)-2-nitrobenzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
nitric acid;
In
acetic anhydride;
at 0 - 20 ℃;
for 0.25h;
DOI:10.3987/com-99-s114
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 86 percent / NaH; 18-crown-6 ether / dimethylformamide; hexane / 12 h / 20 °C
2.1: t-Buli / diethyl ether; pentane / 4 h / -78 °C
2.2: 89 percent / diethyl ether / 4.5 h / -78 °C
3.1: 96 percent / hydroxylamine hydrochloride; pyridine / ethanol / 3 h / 60 °C
4.1: 91 percent / pyridine / 12 h / 20 °C
5.1: 96 percent / liq. ammonia / diethyl ether / 6 h / 20 °C
6.1: 90 percent / t-butyl hypochlorite; Et3N / diethyl ether / -50 - 20 °C
7.1: 93 percent / CSA / methanol / 12 h / 20 °C
8.1: 96 percent / CBr4; PPh3 / toluene / 24 h / 20 °C
9.1: 91 percent / fuming nitric acid / acetic anhydride / 0.25 h / 0 - 20 °C
With
pyridine; 18-crown-6 ether; tert-butylhypochlorite; carbon tetrabromide; camphor-10-sulfonic acid; hydroxylamine hydrochloride; ammonia; tert.-butyl lithium; nitric acid; sodium hydride; triethylamine; triphenylphosphine;
In
methanol; diethyl ether; ethanol; hexane; acetic anhydride; N,N-dimethyl-formamide; toluene; pentane;
1.1: Alkylation / 2.1: Metallation / 2.2: Acylation / 3.1: Condensation / 4.1: Tosylation / 5.1: Cyclization / 6.1: Oxidation / 7.1: desilylation / 8.1: Bromination / 9.1: Nitration;
DOI:10.3987/com-99-s114
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 96 percent / CBr4; PPh3 / toluene / 24 h / 20 °C
2: 91 percent / fuming nitric acid / acetic anhydride / 0.25 h / 0 - 20 °C
With
carbon tetrabromide; nitric acid; triphenylphosphine;
In
acetic anhydride; toluene;
1: Bromination / 2: Nitration;
DOI:10.3987/com-99-s114
