N-Allyloxycarbonyl-O-(3'-O-acetyl-6-N-phenylacetyl-2'-deoxyadenosyl-allyl-phosphato)-L-threonine methoxyethoxyethyl exter

Base Information

Chemical Name:N-Allyloxycarbonyl-O-(3'-O-acetyl-6-N-phenylacetyl-2'-deoxyadenosyl-allyl-phosphato)-L-threonine methoxyethoxyethyl exter
CAS No.:221351-03-7
Molecular Formula:C₃₆H₄₇N₆O₁₄P
Molecular Weight:818.775
Hs Code.:

Synonyms:N-Allyloxycarbonyl-O-(3'-O-acetyl-6-N-phenylacetyl-2'-deoxyadenosyl-allyl-phosphato)-L-threonine methoxyethoxyethyl exter

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Chemical Property of N-Allyloxycarbonyl-O-(3'-O-acetyl-6-N-phenylacetyl-2'-deoxyadenosyl-allyl-phosphato)-L-threonine methoxyethoxyethyl exter

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Technology Process of N-Allyloxycarbonyl-O-(3'-O-acetyl-6-N-phenylacetyl-2'-deoxyadenosyl-allyl-phosphato)-L-threonine methoxyethoxyethyl exter

There total 10 articles about N-Allyloxycarbonyl-O-(3'-O-acetyl-6-N-phenylacetyl-2'-deoxyadenosyl-allyl-phosphato)-L-threonine methoxyethoxyethyl exter which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2S,3R)-3-{[(2R,3S,5R)-3-Acetoxy-5-(6-phenylacetylamino-purin-9-yl)-tetrahydro-furan-2-ylmethoxy]-allyloxy-phosphanyloxy}-2-allyloxycarbonylamino-butyric acid 2-(2-methoxy-ethoxy)-ethyl ester

: 221351-03-7
N-Allyloxycarbonyl-O-(3'-O-acetyl-6-N-phenylacetyl-2'-deoxyadenosyl-allyl-phosphato)-L-threonine methoxyethoxyethyl exter

Guidance literature:: With tert.-butylhydroperoxide; In dichloromethane; at 0 ℃; for 0.166667h; Yield given;
DOI:10.1002/(SICI)1521-3765(19990201)5:2<669::AID-CHEM669>3.0.CO;2-V

Reference yield:

: 64911-19-9
9-((2R,4S,5R)-4-Trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamine

: 221351-03-7
N-Allyloxycarbonyl-O-(3'-O-acetyl-6-N-phenylacetyl-2'-deoxyadenosyl-allyl-phosphato)-L-threonine methoxyethoxyethyl exter

Guidance literature:: Multi-step reaction with 7 steps

1: HOBt, pyridine / acetonitrile / 12 h

2: NH₃, H₂O / 0.17 h

3: 98 percent / pyridine / 3 h / Ambient temperature

4: 80 percent / pyridine / 4 h

5: 78 percent / ZnBr₂ / nitromethane / 0.25 h / Ambient temperature

6: tetrazole / CH₂Cl₂; acetonitrile / 18 h / Ambient temperature

7: t-BuOOH / CH₂Cl₂ / 0.17 h / 0 °C

With pyridine; 1H-tetrazole; tert.-butylhydroperoxide; ammonia; water; benzotriazol-1-ol; zinc dibromide; In nitromethane; dichloromethane; acetonitrile;
DOI:10.1002/(SICI)1521-3765(19990201)5:2<669::AID-CHEM669>3.0.CO;2-V

Reference yield:

: 155138-06-0
6-N-Phenylacetyl-2'-deoxyadenosine

: 221351-03-7
N-Allyloxycarbonyl-O-(3'-O-acetyl-6-N-phenylacetyl-2'-deoxyadenosyl-allyl-phosphato)-L-threonine methoxyethoxyethyl exter

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / pyridine / 3 h / Ambient temperature

2: 80 percent / pyridine / 4 h

3: 78 percent / ZnBr₂ / nitromethane / 0.25 h / Ambient temperature

4: tetrazole / CH₂Cl₂; acetonitrile / 18 h / Ambient temperature

5: t-BuOOH / CH₂Cl₂ / 0.17 h / 0 °C

With pyridine; 1H-tetrazole; tert.-butylhydroperoxide; zinc dibromide; In nitromethane; dichloromethane; acetonitrile;
DOI:10.1002/(SICI)1521-3765(19990201)5:2<669::AID-CHEM669>3.0.CO;2-V