1-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl }carbonyl)piperazine

Base Information

Chemical Name:1-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl }carbonyl)piperazine
CAS No.:1427555-47-2
Molecular Formula:C₂₃H₂₆ClN₅O
Molecular Weight:423.945
Hs Code.:

Synonyms:1-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl }carbonyl)piperazine

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Chemical Property of 1-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl }carbonyl)piperazine

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Technology Process of 1-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl }carbonyl)piperazine

There total 8 articles about 1-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl }carbonyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

: 32315-10-9
bis(trichloromethyl) carbonate

: 1334711-86-2
4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidine

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 1427555-47-2
1-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl }carbonyl)piperazine

Guidance literature:: bis(trichloromethyl) carbonate; 1-t-Butoxycarbonylpiperazine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 18h;

4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidine; With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 24h;

With trifluoroacetic acid; In dichloromethane; for 1h;

Reference yield:

: C₂₈H₃₄ClN₅O₃

: 1427555-47-2
1-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl }carbonyl)piperazine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 1h;

Reference yield:

: 1334711-85-1
tert-butyl 4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidine-1-carboxylate

: 1427555-47-2
1-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl }carbonyl)piperazine

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h

2.1: dmap; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h

2.2: 24 h

3.1: trifluoroacetic acid / dichloromethane / 1 h

With dmap; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;