2(S)-benzyl-3-[hydroxy(1'(R)-aminoethyl)phosphinyl]propanoyl-L-tyrosine

Base Information

Chemical Name:2(S)-benzyl-3-[hydroxy(1'(R)-aminoethyl)phosphinyl]propanoyl-L-tyrosine
CAS No.:287935-84-6
Molecular Formula:C₂₁H₂₇N₂O₆P
Molecular Weight:434.429
Hs Code.:

Synonyms:2(S)-benzyl-3-[hydroxy(1'(R)-aminoethyl)phosphinyl]propanoyl-L-tyrosine

Suppliers and Price of 2(S)-benzyl-3-[hydroxy(1'(R)-aminoethyl)phosphinyl]propanoyl-L-tyrosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2(S)-benzyl-3-[hydroxy(1'(R)-aminoethyl)phosphinyl]propanoyl-L-tyrosine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2(S)-benzyl-3-[hydroxy(1'(R)-aminoethyl)phosphinyl]propanoyl-L-tyrosine

There total 5 articles about 2(S)-benzyl-3-[hydroxy(1'(R)-aminoethyl)phosphinyl]propanoyl-L-tyrosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.8%

: 287935-87-9
2(R,S)-benzyl-3-{hydroxy[1'(R)-(N-benzyloxycarbonylamino)ethyl]phosphinyl}propanoyl-L-tyrosine

: 2(R)-benzyl-3-[hydroxy(1'(R)-aminoethyl)phosphinyl]propanoyl-L-tyrosine

: 287935-84-6
2(S)-benzyl-3-[hydroxy(1'(R)-aminoethyl)phosphinyl]propanoyl-L-tyrosine

Guidance literature:: With hydrogen bromide; In acetic acid; at 20 ℃; for 0.75h;
DOI:10.1002/(SICI)1099-1344(200002)43:2<103::AID-JLCR294>3.0.CO;2-I

Reference yield:

: 3070-71-1
methyl 2-benzylacrylate

: 287935-84-6
2(S)-benzyl-3-[hydroxy(1'(R)-aminoethyl)phosphinyl]propanoyl-L-tyrosine

Guidance literature:: Multi-step reaction with 5 steps

1: 92.2 percent / N,O-bistrimethylsilylacetamide / 70 °C

2: 90.5 percent / aq. NaOH / methanol / 16 h / 20 °C

3: 63.1 percent / diisopropylethylamine; HOBt; EDC / CH₂Cl₂; tetrahydrofuran / 0.75 h / 20 °C

4: 90.2 percent / aq. NaOH / methanol / 8 h / 20 °C

5: 51.8 percent / aq. HBr / acetic acid / 0.75 h / 20 °C

With sodium hydroxide; N,O-bis-(trimethylsilyl)-acetamide; hydrogen bromide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; acetic acid; 1: Addition / 2: Hydrolysis / 3: Acylation / 4: Hydrolysis / 5: Substitution;
DOI:10.1002/(SICI)1099-1344(200002)43:2<103::AID-JLCR294>3.0.CO;2-I

Reference yield:

: 287935-81-3
2(R,S)-benzyl-3-{hydroxy[1'(R)-(N-benzyloxycarbonylamino)ethyl]phosphinyl}propanoic acid

: 287935-84-6
2(S)-benzyl-3-[hydroxy(1'(R)-aminoethyl)phosphinyl]propanoyl-L-tyrosine

Guidance literature:: Multi-step reaction with 3 steps

1: 63.1 percent / diisopropylethylamine; HOBt; EDC / CH₂Cl₂; tetrahydrofuran / 0.75 h / 20 °C

2: 90.2 percent / aq. NaOH / methanol / 8 h / 20 °C

3: 51.8 percent / aq. HBr / acetic acid / 0.75 h / 20 °C

With sodium hydroxide; hydrogen bromide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; acetic acid; 1: Acylation / 2: Hydrolysis / 3: Substitution;
DOI:10.1002/(SICI)1099-1344(200002)43:2<103::AID-JLCR294>3.0.CO;2-I