1-(Carbobenzyloxy)-trans-4-(N-methyl-3',4'-dichlorobenzamido)-3-pyrrolidinylpiperidine

Base Information

• Chemical Name: 1-(Carbobenzyloxy)-trans-4-(N-methyl-3',4'-dichlorobenzamido)-3-pyrrolidinylpiperidine
• CAS No.: 133671-20-2
• Molecular Formula: C₂₅H₂₉Cl₂N₃O₃
• Molecular Weight: 490.43
• Mol file: 133671-20-2.mol

Synonyms:1-(Carbobenzyloxy)-trans-4-(N-methyl-3',4'-dichlorobenzamido)-3-pyrrolidinylpiperidine

Chemical Property of 1-(Carbobenzyloxy)-trans-4-(N-methyl-3',4'-dichlorobenzamido)-3-pyrrolidinylpiperidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(Carbobenzyloxy)-trans-4-(N-methyl-3',4'-dichlorobenzamido)-3-pyrrolidinylpiperidine

There total 5 articles about 1-(Carbobenzyloxy)-trans-4-(N-methyl-3',4'-dichlorobenzamido)-3-pyrrolidinylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-(Carbobenzyloxy)-trans-4-(methylamino)-3-pyrrolidinylpiperidine (133671-15-5) + 3,4-dichlorobenzoyl chloride (3024-72-4) → 1-(Carbobenzyloxy)-trans-4-(N-methyl-3',4'-dichlorobenzamido)-3-pyrrolidinylpiperidine (133671-20-2)

Guidance literature:

With triethylamine; In diethyl ether;

DOI:10.1021/jo00009a038

Reference yield:

1,2,3,6-tetrahydropyridine (694-05-3) → 1-(Carbobenzyloxy)-trans-4-(N-methyl-3',4'-dichlorobenzamido)-3-pyrrolidinylpiperidine (133671-20-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 99 percent / 10percent aq. Na₂CO₃ / 2 h / 0 °C

2: 92 percent / m-CPBA / CH₂Cl₂ / 4 h / 0 deg C to r.t.

4: 90 percent / Et₃N / diethyl ether

With sodium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In diethyl ether; dichloromethane;

DOI:10.1021/jo00009a038

Reference yield:

3,4-epoxy-piperidine-1-carboxylic acid benzyl ester (66207-08-7,1624258-63-4) → 1-(Carbobenzyloxy)-trans-4-(N-methyl-3',4'-dichlorobenzamido)-3-pyrrolidinylpiperidine (133671-20-2)

Guidance literature:

Multi-step reaction with 2 steps

2: 90 percent / Et₃N / diethyl ether

With triethylamine; In diethyl ether;

DOI:10.1021/jo00009a038

upstream raw materials:

1-(Carbobenzyloxy)-trans-4-(methylamino)-3-pyrrolidinylpiperidine

3,4-dichlorobenzoyl chloride

1,2,3,6-tetrahydropyridine

3,4-epoxy-piperidine-1-carboxylic acid benzyl ester

Downstream raw materials:

trans-4-(N-Methyl-3',4'-dichlorobenzamido)-3-pyrrolidinylpiperidine