(S,E)-benzyl (1-((4-oxopent-2-en-1-yl)sulfonyl)-3-phenylpropan-2-yl)carbamate

Base Information

Chemical Name:(S,E)-benzyl (1-((4-oxopent-2-en-1-yl)sulfonyl)-3-phenylpropan-2-yl)carbamate
CAS No.:1334324-83-2
Molecular Formula:C₂₂H₂₅NO₅S
Molecular Weight:415.51
Hs Code.:

Synonyms:(S,E)-benzyl (1-((4-oxopent-2-en-1-yl)sulfonyl)-3-phenylpropan-2-yl)carbamate

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Chemical Property of (S,E)-benzyl (1-((4-oxopent-2-en-1-yl)sulfonyl)-3-phenylpropan-2-yl)carbamate

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Technology Process of (S,E)-benzyl (1-((4-oxopent-2-en-1-yl)sulfonyl)-3-phenylpropan-2-yl)carbamate

There total 4 articles about (S,E)-benzyl (1-((4-oxopent-2-en-1-yl)sulfonyl)-3-phenylpropan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1334324-82-1
(S,E)-benzyl (1-((4-oxopent-2-en-1-yl)thio)-3-phenylpropan-2-yl)carbamate

: 1334324-83-2
(S,E)-benzyl (1-((4-oxopent-2-en-1-yl)sulfonyl)-3-phenylpropan-2-yl)carbamate

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 2.5h; Inert atmosphere;
DOI:10.1021/ol202276h

Reference yield:

: 1334324-91-2
C₂₀H₂₃NO₂S

: 1334324-83-2
(S,E)-benzyl (1-((4-oxopent-2-en-1-yl)sulfonyl)-3-phenylpropan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: Hoveyda-Grubbs catalyst second generation / dichloromethane / 45 °C / Inert atmosphere

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2.5 h / 0 °C / Inert atmosphere

With Hoveyda-Grubbs catalyst second generation; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1021/ol202276h

Reference yield:

: 6372-14-1
N-((benzyloxy)carbonyl)-L-phenylalaninol

: 1334324-83-2
(S,E)-benzyl (1-((4-oxopent-2-en-1-yl)sulfonyl)-3-phenylpropan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: carbon tetrabromide; triphenylphosphine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

3: Hoveyda-Grubbs catalyst second generation / dichloromethane / 45 °C / Inert atmosphere

4: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2.5 h / 0 °C / Inert atmosphere

With Hoveyda-Grubbs catalyst second generation; carbon tetrabromide; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol202276h