4-[(Z)-Phenylimino]-tetrahydro-pyridazine-1,2-dicarboxylic acid diethyl ester

Base Information

• Chemical Name: 4-[(Z)-Phenylimino]-tetrahydro-pyridazine-1,2-dicarboxylic acid diethyl ester
• CAS No.: 149775-51-9
• Molecular Formula: C₁₆H₂₁N₃O₄
• Molecular Weight: 319.36
• Mol file: 149775-51-9.mol

Synonyms:4-[(Z)-Phenylimino]-tetrahydro-pyridazine-1,2-dicarboxylic acid diethyl ester

Chemical Property of 4-[(Z)-Phenylimino]-tetrahydro-pyridazine-1,2-dicarboxylic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-[(Z)-Phenylimino]-tetrahydro-pyridazine-1,2-dicarboxylic acid diethyl ester

There total 1 articles about 4-[(Z)-Phenylimino]-tetrahydro-pyridazine-1,2-dicarboxylic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

aniline (62-53-3) + 1,2-di(ethoxycarbonyl)hexahydropyradizin-4-one (117822-56-7) → 4-[(Z)-Phenylimino]-tetrahydro-pyridazine-1,2-dicarboxylic acid diethyl ester (149775-51-9)

Guidance literature:

With acetic acid; In toluene; Heating;

DOI:10.1007/BF00770619

Reference yield: 77.9%

4-[(Z)-Phenylimino]-tetrahydro-pyridazine-1,2-dicarboxylic acid diethyl ester (149775-51-9) → 1,2-di(ethoxycarbonyl)-4-anilinohexahydropyridazine (149775-53-1)

Guidance literature:

With sodium tetrahydroborate; In methanol; for 6h;

DOI:10.1007/BF00770619

Reference yield:

4-[(Z)-Phenylimino]-tetrahydro-pyridazine-1,2-dicarboxylic acid diethyl ester (149775-51-9) → N-(1,2-Dimethyl-hexahydro-pyridazin-4-yl)-N-phenyl-acetamide

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / LiAlH₄ / diethyl ether / 6 h

2: 55 percent / triethylamine / benzene / 0.5 h / Heating

With lithium aluminium tetrahydride; triethylamine; In diethyl ether; benzene;

DOI:10.1007/BF00770619

upstream raw materials:

aniline

1,2-di(ethoxycarbonyl)hexahydropyradizin-4-one

Downstream raw materials:

1,2-di(ethoxycarbonyl)-4-anilinohexahydropyridazine