(2R,3R,8R)-3-Hydroxy-13-methoxycarbonyl-8,10,12-trimethyl-2-(triphenylmethoxymethyl)trideca-10,12-dienoic acid

Base Information

Chemical Name:(2R,3R,8R)-3-Hydroxy-13-methoxycarbonyl-8,10,12-trimethyl-2-(triphenylmethoxymethyl)trideca-10,12-dienoic acid
CAS No.:136155-26-5
Molecular Formula:C₃₈H₄₆O₆
Molecular Weight:598.78
Hs Code.:

Synonyms:(2R,3R,8R)-3-Hydroxy-13-methoxycarbonyl-8,10,12-trimethyl-2-(triphenylmethoxymethyl)trideca-10,12-dienoic acid

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Chemical Property of (2R,3R,8R)-3-Hydroxy-13-methoxycarbonyl-8,10,12-trimethyl-2-(triphenylmethoxymethyl)trideca-10,12-dienoic acid

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Technology Process of (2R,3R,8R)-3-Hydroxy-13-methoxycarbonyl-8,10,12-trimethyl-2-(triphenylmethoxymethyl)trideca-10,12-dienoic acid

There total 7 articles about (2R,3R,8R)-3-Hydroxy-13-methoxycarbonyl-8,10,12-trimethyl-2-(triphenylmethoxymethyl)trideca-10,12-dienoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 76-83-5
trityl chloride

: 136155-25-4
(2R,3R,8R)-3-Hydroxy-2-hydroxymethyl-13-methoxycarbonyl-8,10,12-trimethyltrideca-10,12-dienoic acid

: 136155-26-5
(2R,3R,8R)-3-Hydroxy-13-methoxycarbonyl-8,10,12-trimethyl-2-(triphenylmethoxymethyl)trideca-10,12-dienoic acid

Guidance literature:: With pyridine; at 70 ℃; for 12h;

Reference yield:

: 62924-29-2
(E)-4-Dimethylphosphono-3-methyl-2-butenoate

: 136155-26-5
(2R,3R,8R)-3-Hydroxy-13-methoxycarbonyl-8,10,12-trimethyl-2-(triphenylmethoxymethyl)trideca-10,12-dienoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 1) KH / 1) THF, mineral oil, r.t., 15 min, 2) THF, 40 deg C, 2 d

2: 75 percent / 1 M tetra(n-butyl)ammonium fluoride / tetrahydrofuran / 3 h / 0 °C

3: 1a) oxalyl chloride, DMSO, 2) Et₃N / 1a) CH₂Cl₂, -78 deg C, 15 min, b) -78 deg C, 1 h, 2) -78 to 0 deg C

4: 95 percent / NaClO₂, NaH₂PO₄*2H₂O, 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 0.5 h / Ambient temperature

5: Amberlyst-15 / methanol / 12 h / Ambient temperature

6: 85 percent / pyridine / 12 h / 70 °C

With pyridine; sodium chlorite; sodium dihydrogenphosphate; amberlyst-15; 2-methyl-but-2-ene; oxalyl dichloride; tetrabutyl ammonium fluoride; potassium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; water; tert-butyl alcohol;

Reference yield:

: 136155-23-2
Methyl (7R,12R,13R)-13-formyl-12,14-isopropylidenedioxy-3,5,7-trimethyltetradeca-2,4-dienoate

: 136155-26-5
(2R,3R,8R)-3-Hydroxy-13-methoxycarbonyl-8,10,12-trimethyl-2-(triphenylmethoxymethyl)trideca-10,12-dienoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / NaClO₂, NaH₂PO₄*2H₂O, 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 0.5 h / Ambient temperature

2: Amberlyst-15 / methanol / 12 h / Ambient temperature

3: 85 percent / pyridine / 12 h / 70 °C

With pyridine; sodium chlorite; sodium dihydrogenphosphate; amberlyst-15; 2-methyl-but-2-ene; In methanol; water; tert-butyl alcohol;