5-(2-fluoro-6-methoxyphenyl)-1-(4-(trifluoromethoxy)benzyl)pyrrolidine-2,3-dione

Base Information

Chemical Name:5-(2-fluoro-6-methoxyphenyl)-1-(4-(trifluoromethoxy)benzyl)pyrrolidine-2,3-dione
CAS No.:1375098-84-2
Molecular Formula:C₁₉H₁₅F₄NO₄
Molecular Weight:397.326
Hs Code.:

Synonyms:5-(2-fluoro-6-methoxyphenyl)-1-(4-(trifluoromethoxy)benzyl)pyrrolidine-2,3-dione

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Chemical Property of 5-(2-fluoro-6-methoxyphenyl)-1-(4-(trifluoromethoxy)benzyl)pyrrolidine-2,3-dione

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Technology Process of 5-(2-fluoro-6-methoxyphenyl)-1-(4-(trifluoromethoxy)benzyl)pyrrolidine-2,3-dione

There total 2 articles about 5-(2-fluoro-6-methoxyphenyl)-1-(4-(trifluoromethoxy)benzyl)pyrrolidine-2,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1375098-83-1
ethyl 2-(2-fluoro-6-methoxyphenyl)-4,5-dioxo-1-(4-(trifluoromethoxy)benzyl)pyrrolidine-3-carboxylate

: 1375098-84-2
5-(2-fluoro-6-methoxyphenyl)-1-(4-(trifluoromethoxy)benzyl)pyrrolidine-2,3-dione

Guidance literature:: ethyl 2-(2-fluoro-6-methoxyphenyl)-4,5-dioxo-1-(4-(trifluoromethoxy)benzyl)pyrrolidine-3-carboxylate; With hydrogenchloride; In 1,4-dioxane; water; for 11h; Reflux; Inert atmosphere;

With sodium hydrogencarbonate; In 1,4-dioxane; dichloromethane; water; at 20 ℃;

Reference yield:

: 146137-74-8
2-fluoro-6-methoxybenzaldehyde

: 93919-56-3
4-(trifluoromethoxy)benzyl amine

: 1375098-84-2
5-(2-fluoro-6-methoxyphenyl)-1-(4-(trifluoromethoxy)benzyl)pyrrolidine-2,3-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(II) sulfate / ethyl acetate / 3 h / Reflux; Inert atmosphere

2.1: hydrogenchloride / 1,4-dioxane; water / 11 h / Reflux; Inert atmosphere

2.2: 20 °C

With hydrogenchloride; copper(II) sulfate; In 1,4-dioxane; water; ethyl acetate;