cyanoethyl 3'-O-(5'-O-dimethoxytrityl)thymidinyl-5'-C(S)-tosyloxyethyl-(3'-tert-butyldiphenylsilyl)thymidinyl thiophosphoric ester

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Chemical Name:cyanoethyl 3'-O-(5'-O-dimethoxytrityl)thymidinyl-5'-C(S)-tosyloxyethyl-(3'-tert-butyldiphenylsilyl)thymidinyl thiophosphoric ester
CAS No.:943002-10-6
Molecular Formula:C₆₉H₇₆N₅O₁₆PS₂Si
Molecular Weight:1354.58
Hs Code.:

Synonyms:cyanoethyl 3'-O-(5'-O-dimethoxytrityl)thymidinyl-5'-C(S)-tosyloxyethyl-(3'-tert-butyldiphenylsilyl)thymidinyl thiophosphoric ester

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Chemical Property of cyanoethyl 3'-O-(5'-O-dimethoxytrityl)thymidinyl-5'-C(S)-tosyloxyethyl-(3'-tert-butyldiphenylsilyl)thymidinyl thiophosphoric ester

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Technology Process of cyanoethyl 3'-O-(5'-O-dimethoxytrityl)thymidinyl-5'-C(S)-tosyloxyethyl-(3'-tert-butyldiphenylsilyl)thymidinyl thiophosphoric ester

There total 1 articles about cyanoethyl 3'-O-(5'-O-dimethoxytrityl)thymidinyl-5'-C(S)-tosyloxyethyl-(3'-tert-butyldiphenylsilyl)thymidinyl thiophosphoric ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 494798-47-9
5′-C(S)-tosyloxyethyl-3′-O-(tert-butyldiphenylsilyl)thymidine

: 943002-10-6
cyanoethyl 3'-O-(5'-O-dimethoxytrityl)thymidinyl-5'-C(S)-tosyloxyethyl-(3'-tert-butyldiphenylsilyl)thymidinyl thiophosphoric ester

: 943002-11-7
cyanoethyl 3'-O-(5'-O-dimethoxytrityl)thymidinyl-5'-C(S)-tosyloxyethyl-(3'-tert-butyldiphenylsilyl)thymidinyl thiophosphoric ester

Guidance literature:: 5′-C(S)-tosyloxyethyl-3′-O-(tert-butyldiphenylsilyl)thymidine; thymidine O_3'-phosphoramidite; With 1H-tetrazole; In acetonitrile; at 20 ℃; for 0.75h;

With pyridine; sulfur; In toluene; acetonitrile; for 1h; Further stages.;
DOI:10.1002/ejoc.200601030

Reference yield: 95.0%

: 943002-10-6
cyanoethyl 3'-O-(5'-O-dimethoxytrityl)thymidinyl-5'-C(S)-tosyloxyethyl-(3'-tert-butyldiphenylsilyl)thymidinyl thiophosphoric ester

: 943002-12-8
5′-O-dimethoxytrityl-3′-O-tert-butyldiphenylsilyl-thio-α,β,-D-CNA(S_c,R_P)

Guidance literature:: With potassium carbonate; cadmium(II) chloride; In N,N-dimethyl-formamide; at 20 ℃; for 432h;
DOI:10.1002/ejoc.200601030