pyrimidine-4,6-dicarboxylic acid 4-{[dideutero-(4-formyl-phenyl)-methyl]-amide} 6-(4-fluoro-3-methyl-benzylamide)

Base Information

Chemical Name:pyrimidine-4,6-dicarboxylic acid 4-{[dideutero-(4-formyl-phenyl)-methyl]-amide} 6-(4-fluoro-3-methyl-benzylamide)
CAS No.:1605324-97-7
Molecular Formula:C₂₂H₁₉FN₄O₃
Molecular Weight:408.4
Hs Code.:

Synonyms:pyrimidine-4,6-dicarboxylic acid 4-{[dideutero-(4-formyl-phenyl)-methyl]-amide} 6-(4-fluoro-3-methyl-benzylamide)

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Chemical Property of pyrimidine-4,6-dicarboxylic acid 4-{[dideutero-(4-formyl-phenyl)-methyl]-amide} 6-(4-fluoro-3-methyl-benzylamide)

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Technology Process of pyrimidine-4,6-dicarboxylic acid 4-{[dideutero-(4-formyl-phenyl)-methyl]-amide} 6-(4-fluoro-3-methyl-benzylamide)

There total 2 articles about pyrimidine-4,6-dicarboxylic acid 4-{[dideutero-(4-formyl-phenyl)-methyl]-amide} 6-(4-fluoro-3-methyl-benzylamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 690998-35-7
6-(4-fluoro-3-methyl-benzylcarbamoyl)-pyrimidine-4-carboxylic acid

: 1605324-96-6
4-(amino-dideutero-methyl)-benzaldehyde hydrochloride

: 1605324-97-7
pyrimidine-4,6-dicarboxylic acid 4-{[dideutero-(4-formyl-phenyl)-methyl]-amide} 6-(4-fluoro-3-methyl-benzylamide)

Guidance literature:: 6-(4-fluoro-3-methyl-benzylcarbamoyl)-pyrimidine-4-carboxylic acid; 4-(amino-dideutero-methyl)-benzaldehyde hydrochloride; With 1-hydroxy-7-aza-benzotriazole; In N,N-dimethyl-formamide; for 0.0333333 - 0.05h;

With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

: 90921-71-4
4-(dimethoxymethyl)benzonitrile

: 1605324-97-7
pyrimidine-4,6-dicarboxylic acid 4-{[dideutero-(4-formyl-phenyl)-methyl]-amide} 6-(4-fluoro-3-methyl-benzylamide)

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium deuteride / tetrahydrofuran / 0 - 20 °C

1.3: 10 h

2.1: 1-hydroxy-7-aza-benzotriazole / N,N-dimethyl-formamide / 0.03 - 0.05 h

2.2: 1 h / 20 °C

With 1-hydroxy-7-aza-benzotriazole; lithium aluminium deuteride; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield: 38.0%

: 1605324-97-7
pyrimidine-4,6-dicarboxylic acid 4-{[dideutero-(4-formyl-phenyl)-methyl]-amide} 6-(4-fluoro-3-methyl-benzylamide)

: 1605324-98-8
4-(dideutero-{[6-(4-fluoro-3-methyl-benzylcarbamoyl)-pyrimidine-4-carbonyl]-amino}-methyl)-benzoic acid

Guidance literature:: pyrimidine-4,6-dicarboxylic acid 4-{[dideutero-(4-formyl-phenyl)-methyl]-amide} 6-(4-fluoro-3-methyl-benzylamide); With aminosulfonic acid; In acetic acid; for 10h;

With sodium chlorite; In water; acetic acid; at 20 ℃; for 3h;